Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 777556..778213 Replicon chromosome
Accession NZ_CP058758
Organism Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HZT06_RS03925 Protein ID WP_002916310.1
Coordinates 777803..778213 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HZT06_RS03920 Protein ID WP_002916312.1
Coordinates 777556..777822 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT06_RS03895 (HZT06_03895) 772712..774145 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
HZT06_RS03900 (HZT06_03900) 774264..774992 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HZT06_RS03905 (HZT06_03905) 775042..775353 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HZT06_RS03910 (HZT06_03910) 775517..776176 + 660 WP_002916317.1 hemolysin III family protein -
HZT06_RS03915 (HZT06_03915) 776327..777310 - 984 WP_240730594.1 tRNA-modifying protein YgfZ -
HZT06_RS03920 (HZT06_03920) 777556..777822 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HZT06_RS03925 (HZT06_03925) 777803..778213 + 411 WP_002916310.1 protein YgfX Toxin
HZT06_RS03930 (HZT06_03930) 778220..778741 - 522 WP_004144730.1 flavodoxin FldB -
HZT06_RS03935 (HZT06_03935) 778842..779738 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HZT06_RS03940 (HZT06_03940) 779761..780474 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZT06_RS03945 (HZT06_03945) 780480..782213 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T167391 WP_002916310.1 NZ_CP058758:777803-778213 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T167391 NZ_CP075122:310524-310892 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT167391 WP_002916312.1 NZ_CP058758:777556-777822 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167391 NZ_CP075122:310306-310527 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References