Detailed information of TA system TA167387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 200869..201608
• Replicon: chromosome
• Accession: NZ_CP058758
• Organism: Klebsiella pneumoniae strain STLIN_3

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: HZT06_RS00995
• Protein ID: WP_021312536.1
• Coordinates: 201123..201608 (+)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: L7SZ29
• Locus tag: HZT06_RS00990
• Protein ID: WP_003026799.1
• Coordinates: 200869..201135 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT06_RS00975 (HZT06_00970)	196373..198442	+	2070	WP_002922127.1	glycine--tRNA ligase subunit beta	-
HZT06_RS00980 (HZT06_00975)	198738..200107	+	1370	WP_240730550.1	IS3 family transposase	-
HZT06_RS00985 (HZT06_00980)	200308..200736	+	429	WP_004901287.1	GFA family protein	-
HZT06_RS00990 (HZT06_00985)	200869..201135	+	267	WP_003026799.1	DUF1778 domain-containing protein	Antitoxin
HZT06_RS00995 (HZT06_00990)	201123..201608	+	486	WP_021312536.1	GNAT family N-acetyltransferase	Toxin
HZT06_RS01000 (HZT06_00995)	201952..202104	+	153	WP_002922102.1	type I toxin-antitoxin system toxin HokA	-
HZT06_RS01005 (HZT06_01000)	202406..204025	+	1620	WP_065901027.1	ATP-binding cassette domain-containing protein	-
HZT06_RS01010 (HZT06_01005)	204123..204335	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
HZT06_RS01015 (HZT06_01010)	204588..204878	-	291	WP_002921931.1	HTH-type transcriptional regulator	-
HZT06_RS01020 (HZT06_01015)	205124..206479	-	1356	WP_240730551.1	aromatic acid/H+ symport family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	199382..200107	725

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (45-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17608.39 Da
• Isoelectric Point: 10.3370

>T167387 WP_021312536.1 NZ_CP058758:201123-201608 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T167387 NZ_CP075120:c4488516-4488205 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10147.59 Da
• Isoelectric Point: 4.5256

>AT167387 WP_003026799.1 NZ_CP058758:200869-201135 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT167387 NZ_CP075120:c4488204-4487914 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1Q8YL66