Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 14214..14739 Replicon plasmid unnamed3
Accession NZ_CP058755
Organism Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag HZT05_RS27495 Protein ID WP_013023785.1
Coordinates 14434..14739 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag HZT05_RS27490 Protein ID WP_001568025.1
Coordinates 14214..14432 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT05_RS27470 (HZT05_27355) 9370..10149 + 780 WP_013023780.1 hypothetical protein -
HZT05_RS27475 (HZT05_27360) 10425..11948 + 1524 WP_017899887.1 hypothetical protein -
HZT05_RS27480 (HZT05_27365) 11982..13109 + 1128 WP_013023782.1 DUF4238 domain-containing protein -
HZT05_RS27485 (HZT05_27370) 13106..13396 + 291 WP_013023783.1 hypothetical protein -
HZT05_RS27490 (HZT05_27375) 14214..14432 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HZT05_RS27495 (HZT05_27380) 14434..14739 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
HZT05_RS27500 (HZT05_27385) 14908..15303 + 396 WP_017899885.1 hypothetical protein -
HZT05_RS27505 (HZT05_27390) 15330..15644 + 315 WP_053389906.1 hypothetical protein -
HZT05_RS27510 (HZT05_27395) 15655..16671 + 1017 WP_017899884.1 hypothetical protein -
HZT05_RS27515 (HZT05_27400) 16869..17663 + 795 WP_004197635.1 site-specific integrase -
HZT05_RS27520 18159..18461 - 303 WP_004197636.1 hypothetical protein -
HZT05_RS27525 (HZT05_27410) 18458..19084 - 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS1 / blaCTX-M-3 / blaTEM-1B / floR / tet(A) / mph(A) / sul1 / qnrB91 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr / aph(3')-Ia / aac(3)-IId / aph(6)-Id / aph(3'')-Ib / sul2 - 1..97014 97014


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T167386 WP_013023785.1 NZ_CP058755:14434-14739 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T167386 NZ_CP075120:c4179285-4178794 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT167386 WP_001568025.1 NZ_CP058755:14214-14432 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT167386 NZ_CP075120:c4179575-4179282 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References