Detailed information of TA system TA167384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 26407..26929
• Replicon: plasmid unnamed1
• Accession: NZ_CP058753
• Organism: Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A9J6S4Z8
• Locus tag: HZT05_RS26260
• Protein ID: WP_004187019.1
• Coordinates: 26407..26691 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A2J4ZSR4
• Locus tag: HZT05_RS26265
• Protein ID: WP_004187025.1
• Coordinates: 26681..26929 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT05_RS26240 (HZT05_26145)	21626..22090	-	465	WP_004187010.1	conjugative transfer protein MobI(A/C)	-
HZT05_RS26245 (HZT05_26150)	23633..24046	+	414	WP_004187013.1	hypothetical protein	-
HZT05_RS26250	24703..24954	+	252	Protein_20	conjugal transfer protein TraH	-
HZT05_RS26255 (HZT05_26160)	25036..26391	+	1356	WP_240726561.1	ISNCY family transposase	-
HZT05_RS26260 (HZT05_26165)	26407..26691	-	285	WP_004187019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZT05_RS26265 (HZT05_26170)	26681..26929	-	249	WP_004187025.1	plasmid stabilization protein	Antitoxin
HZT05_RS26270 (HZT05_26175)	27219..27643	-	425	Protein_24	IS1 family transposase	-
HZT05_RS26275 (HZT05_26180)	27828..27944	-	117	Protein_25	transposase domain-containing protein	-
HZT05_RS26280 (HZT05_26185)	27889..28152	-	264	WP_004118209.1	transposase	-
HZT05_RS26285 (HZT05_26190)	28167..28430	+	264	WP_004118208.1	hypothetical protein	-
HZT05_RS26290	28652..28933	+	282	WP_240726562.1	helix-turn-helix domain-containing protein	-
HZT05_RS26295 (HZT05_26200)	28968..29537	+	570	WP_004152117.1	small heat shock protein sHSP20	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..128688	128688
	-	flank	IS/Tn	-	-	27183..27449	266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11003.72 Da
• Isoelectric Point: 10.5388

>T167384 WP_004187019.1 NZ_CP058753:c26691-26407 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Nucleotide

• Length: 285 bp

>T167384 NZ_CP075120:c4031092-4030784 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9011.24 Da
• Isoelectric Point: 3.9947

>AT167384 WP_004187025.1 NZ_CP058753:c26929-26681 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT167384 NZ_CP075120:c4031334-4031095 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2J4ZSR4