Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4795182..4795839 Replicon chromosome
Accession NZ_CP058752
Organism Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HZT05_RS23610 Protein ID WP_002916310.1
Coordinates 4795429..4795839 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HZT05_RS23605 Protein ID WP_002916312.1
Coordinates 4795182..4795448 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT05_RS23580 (4790338) 4790338..4791771 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HZT05_RS23585 (4791890) 4791890..4792618 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HZT05_RS23590 (4792668) 4792668..4792979 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HZT05_RS23595 (4793143) 4793143..4793802 + 660 WP_002916317.1 hemolysin III family protein -
HZT05_RS23600 (4793953) 4793953..4794936 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HZT05_RS23605 (4795182) 4795182..4795448 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HZT05_RS23610 (4795429) 4795429..4795839 + 411 WP_002916310.1 protein YgfX Toxin
HZT05_RS23615 (4795846) 4795846..4796367 - 522 WP_002916308.1 flavodoxin FldB -
HZT05_RS23620 (4796468) 4796468..4797364 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HZT05_RS23625 (4797387) 4797387..4798100 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZT05_RS23630 (4798106) 4798106..4799839 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T167383 WP_002916310.1 NZ_CP058752:4795429-4795839 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T167383 NZ_CP075120:c3981107-3980820 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT167383 WP_002916312.1 NZ_CP058752:4795182-4795448 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167383 NZ_CP075120:c3980833-3980531 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References