Detailed information of TA system TA167380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4257160..4257746
• Replicon: chromosome
• Accession: NZ_CP058752
• Organism: Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)

• Gene name: doc
• Uniprot ID: W8VD46
• Locus tag: HZT05_RS20795
• Protein ID: WP_002920800.1
• Coordinates: 4257378..4257746 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: W9B1V1
• Locus tag: HZT05_RS20790
• Protein ID: WP_004174006.1
• Coordinates: 4257160..4257381 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT05_RS20770 (4253317)	4253317..4254243	+	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
HZT05_RS20775 (4254240)	4254240..4255517	+	1278	WP_004188292.1	branched chain amino acid ABC transporter permease LivM	-
HZT05_RS20780 (4255514)	4255514..4256281	+	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
HZT05_RS20785 (4256283)	4256283..4256996	+	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
HZT05_RS20790 (4257160)	4257160..4257381	+	222	WP_004174006.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HZT05_RS20795 (4257378)	4257378..4257746	+	369	WP_002920800.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HZT05_RS20800 (4258019)	4258019..4259335	+	1317	WP_004174008.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
HZT05_RS20805 (4259442)	4259442..4260329	+	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
HZT05_RS20810 (4260326)	4260326..4261171	+	846	WP_004145129.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
HZT05_RS20815 (4261173)	4261173..4262243	+	1071	WP_004150074.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4252146..4262980	10834

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13552.92 Da
• Isoelectric Point: 8.6410

>T167380 WP_002920800.1 NZ_CP058752:4257378-4257746 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T167380 NZ_CP058752:4257378-4257746 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8151.15 Da
• Isoelectric Point: 4.7769

>AT167380 WP_004174006.1 NZ_CP058752:4257160-4257381 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT167380 NZ_CP058752:4257160-4257381 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0H3GUD1

Antitoxin

• AlphaFold DB: A0A5E5YJY7