Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3853433..3854058 Replicon chromosome
Accession NZ_CP058752
Organism Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HZT05_RS18925 Protein ID WP_021312635.1
Coordinates 3853433..3853816 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag HZT05_RS18930 Protein ID WP_004150355.1
Coordinates 3853816..3854058 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT05_RS18910 (3850799) 3850799..3851701 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
HZT05_RS18915 (3851698) 3851698..3852333 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
HZT05_RS18920 (3852330) 3852330..3853259 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
HZT05_RS18925 (3853433) 3853433..3853816 - 384 WP_021312635.1 type II toxin-antitoxin system VapC family toxin Toxin
HZT05_RS18930 (3853816) 3853816..3854058 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
HZT05_RS18935 (3854263) 3854263..3855180 + 918 WP_004187929.1 alpha/beta hydrolase -
HZT05_RS18940 (3855194) 3855194..3856135 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
HZT05_RS18945 (3856180) 3856180..3856617 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
HZT05_RS18950 (3856614) 3856614..3857474 - 861 WP_004146232.1 virulence factor BrkB family protein -
HZT05_RS18955 (3857468) 3857468..3858067 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14349.56 Da        Isoelectric Point: 7.3178

>T167379 WP_021312635.1 NZ_CP058752:c3853816-3853433 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVATPYEIHPE

Download         Length: 384 bp

>T167379 NZ_CP075120:c2437388-2437233 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT167379 WP_004150355.1 NZ_CP058752:c3854058-3853816 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT167379 NZ_CP075120:2437400-2437458 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References