Detailed information of TA system TA167376

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 3288381..3289072
• Replicon: chromosome
• Accession: NZ_CP058752
• Organism: Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HZT05_RS16280
• Protein ID: WP_216422548.1
• Coordinates: 3288381..3288722 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A2A5MHA6
• Locus tag: HZT05_RS16285
• Protein ID: WP_019725272.1
• Coordinates: 3288746..3289072 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT05_RS16265 (3285361)	3285361..3286596	-	1236	WP_141400004.1	hypothetical protein	-
HZT05_RS16270 (3287035)	3287035..3287406	-	372	WP_240726111.1	hypothetical protein	-
HZT05_RS16275 (3287433)	3287433..3288266	-	834	WP_025987720.1	DUF4942 domain-containing protein	-
HZT05_RS16280 (3288381)	3288381..3288722	-	342	WP_216422548.1	TA system toxin CbtA family protein	Toxin
HZT05_RS16285 (3288746)	3288746..3289072	-	327	WP_019725272.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HZT05_RS16290 (3289086)	3289086..3289562	-	477	WP_019725273.1	DNA repair protein RadC	-
HZT05_RS16295 (3289572)	3289572..3290018	-	447	WP_025987722.1	antirestriction protein	-
HZT05_RS16300 (3290230)	3290230..3290919	-	690	WP_009309812.1	hypothetical protein	-
HZT05_RS16305 (3291484)	3291484..3292374	-	891	WP_019725276.1	YfjP family GTPase	-
HZT05_RS16310 (3292457)	3292457..3293545	-	1089	WP_216422887.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3271851..3311762	39911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12920.01 Da
• Isoelectric Point: 10.3418

>T167376 WP_216422548.1 NZ_CP058752:c3288722-3288381 [Klebsiella pneumoniae]
MKTLPATIQRAAKPRPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQKHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Nucleotide

• Length: 342 bp

>T167376 NZ_CP075120:825270-825683 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12276.01 Da
• Isoelectric Point: 6.9560

>AT167376 WP_019725272.1 NZ_CP058752:c3289072-3288746 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Nucleotide

• Length: 327 bp

>AT167376 NZ_CP075120:825023-825289 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MHA6