Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2641346..2641965 Replicon chromosome
Accession NZ_CP058752
Organism Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HZT05_RS13155 Protein ID WP_002892050.1
Coordinates 2641747..2641965 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HZT05_RS13150 Protein ID WP_002892066.1
Coordinates 2641346..2641720 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT05_RS13140 (2636498) 2636498..2637691 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT05_RS13145 (2637714) 2637714..2640860 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HZT05_RS13150 (2641346) 2641346..2641720 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HZT05_RS13155 (2641747) 2641747..2641965 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HZT05_RS13160 (2642124) 2642124..2642690 + 567 WP_002892030.1 maltose O-acetyltransferase -
HZT05_RS13165 (2642662) 2642662..2642802 - 141 WP_004147370.1 hypothetical protein -
HZT05_RS13170 (2642823) 2642823..2643293 + 471 WP_002892026.1 YlaC family protein -
HZT05_RS13175 (2643268) 2643268..2644719 - 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
HZT05_RS13180 (2644820) 2644820..2645518 + 699 WP_002892021.1 GNAT family protein -
HZT05_RS13185 (2645515) 2645515..2645655 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HZT05_RS13190 (2645655) 2645655..2645918 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167374 WP_002892050.1 NZ_CP058752:2641747-2641965 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T167374 NZ_CP075120:310524-310892 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT167374 WP_002892066.1 NZ_CP058752:2641346-2641720 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT167374 NZ_CP075120:310306-310527 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References