Detailed information of TA system TA167372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1288166..1289754
• Replicon: chromosome
• Accession: NZ_CP058752
• Organism: Klebsiella pneumoniae strain STLIN_19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HZT05_RS06490
• Protein ID: WP_240726369.1
• Coordinates: 1288166..1289488 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HZT05_RS06495
• Protein ID: WP_002904790.1
• Coordinates: 1289488..1289754 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT05_RS06475 (1283231)	1283231..1285732	+	2502	WP_240726368.1	fimbria/pilus outer membrane usher protein	-
HZT05_RS06480 (1285720)	1285720..1286724	+	1005	WP_023286423.1	fimbrial protein	-
HZT05_RS06485 (1286857)	1286857..1288149	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HZT05_RS06490 (1288166)	1288166..1289488	-	1323	WP_240726369.1	type II toxin-antitoxin system HipA family toxin	Toxin
HZT05_RS06495 (1289488)	1289488..1289754	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HZT05_RS06500 (1290019)	1290019..1290345	-	327	WP_004143476.1	hydroxyisourate hydrolase	-
HZT05_RS06505 (1290342)	1290342..1290842	-	501	WP_240726370.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HZT05_RS06510 (1290820)	1290820..1292199	-	1380	WP_048299445.1	nucleobase:cation symporter-2 family protein	-
HZT05_RS06515 (1292545)	1292545..1293699	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HZT05_RS06520 (1293680)	1293680..1294603	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49084.38 Da
• Isoelectric Point: 7.2487

>T167372 WP_240726369.1 NZ_CP058752:c1289488-1288166 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T167372 NZ_CP075119:c14802-14497 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT167372 WP_002904790.1 NZ_CP058752:c1289754-1289488 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT167372 NZ_CP075119:c15022-14804 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8