Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 10969..11570 Replicon plasmid unnamed2
Accession NZ_CP058750
Organism Escherichia coli strain STLIN_13

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HZS99_RS24125 Protein ID WP_121855399.1
Coordinates 11190..11570 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag HZS99_RS24120 Protein ID WP_001190712.1
Coordinates 10969..11190 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS99_RS24080 (HZS99_23900) 6244..6432 + 189 WP_000797279.1 hypothetical protein -
HZS99_RS24085 (HZS99_23905) 6434..6612 + 179 Protein_10 hypothetical protein -
HZS99_RS24090 6946..7080 + 135 Protein_11 hypothetical protein -
HZS99_RS24095 (HZS99_23910) 7072..7956 + 885 WP_225902472.1 hypothetical protein -
HZS99_RS24100 (HZS99_23915) 7953..8315 + 363 WP_001261543.1 hypothetical protein -
HZS99_RS24105 (HZS99_23920) 9391..9747 - 357 WP_032272825.1 hypothetical protein -
HZS99_RS24110 (HZS99_23925) 9748..10332 - 585 WP_032272826.1 hypothetical protein -
HZS99_RS24115 (HZS99_23930) 10507..10896 + 390 WP_000506730.1 S24 family peptidase -
HZS99_RS24120 (HZS99_23935) 10969..11190 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZS99_RS24125 (HZS99_23940) 11190..11570 + 381 WP_121855399.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HZS99_RS24130 (HZS99_23945) 11575..11754 + 180 WP_000113018.1 hypothetical protein -
HZS99_RS24135 (HZS99_23950) 11782..12825 + 1044 WP_208557430.1 DUF968 domain-containing protein -
HZS99_RS24140 (HZS99_23955) 12914..13366 + 453 WP_001326849.1 late promoter-activating protein -
HZS99_RS24145 (HZS99_23960) 13452..14645 + 1194 WP_032153803.1 hypothetical protein -
HZS99_RS24150 (HZS99_23965) 14687..16129 + 1443 WP_001472843.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95942 95942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13621.28 Da        Isoelectric Point: 5.1514

>T167363 WP_121855399.1 NZ_CP058750:11190-11570 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSSE

Download         Length: 381 bp

>T167363 NZ_CP075118:c2687162-2687059 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT167363 WP_001190712.1 NZ_CP058750:10969-11190 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT167363 NZ_CP075118:2687057-2687202 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References