Detailed information of TA system TA167350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3172817..3173522
• Replicon: chromosome
• Accession: NZ_CP058748
• Organism: Escherichia coli strain STLIN_13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1M2J6W7
• Locus tag: HZS99_RS15235
• Protein ID: WP_000539524.1
• Coordinates: 3172817..3173203 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HZS99_RS15240
• Protein ID: WP_001280945.1
• Coordinates: 3173193..3173522 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS99_RS15215 (3168821)	3168821..3169447	+	627	WP_001295292.1	glutathione S-transferase GstB	-
HZS99_RS15220 (3169444)	3169444..3170559	-	1116	WP_000555056.1	aldose sugar dehydrogenase YliI	-
HZS99_RS15225 (3170670)	3170670..3171053	-	384	WP_000497137.1	biofilm formation regulator BssR	-
HZS99_RS15230 (3171266)	3171266..3172591	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
HZS99_RS15235 (3172817)	3172817..3173203	+	387	WP_000539524.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZS99_RS15240 (3173193)	3173193..3173522	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
HZS99_RS15245 (3173592)	3173592..3174909	-	1318	Protein_3003	diguanylate cyclase	-
HZS99_RS15250 (3174917)	3174917..3177265	-	2349	WP_000950331.1	EAL domain-containing protein	-
HZS99_RS15255 (3177442)	3177442..3178353	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14321.46 Da
• Isoelectric Point: 9.9521

>T167350 WP_000539524.1 NZ_CP058748:3172817-3173203 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T167350 NZ_CP075116:3546545-3546808 [Salmonella enterica subsp. enterica serovar Stanleyville]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGGCGAGCGTTGTTGTGAAGATCTCCGAGCGGGGTTTGATCCTGATTG
CAGAAACGGATGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATTAAGGCGGGGGTA
AATAATGTGGTGAACGGGAATTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT167350 WP_001280945.1 NZ_CP058748:3173193-3173522 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT167350 NZ_CP075116:c3546798-3546388 [Salmonella enterica subsp. enterica serovar Stanleyville]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCATCCGTTTCTGCAATCAGGATCAAACCCCGCTCGGAGATCTTCACAACAACGCTCGCCCCGGTCTCAAATCCCGCTT
CTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCG
CCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAG
CGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCCGG
GGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A1M2J6W7