Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 842136..842968 Replicon chromosome
Accession NZ_CP058748
Organism Escherichia coli strain STLIN_13

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag HZS99_RS04090 Protein ID WP_001094454.1
Coordinates 842136..842510 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag HZS99_RS04095 Protein ID WP_001320394.1
Coordinates 842600..842968 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS99_RS04060 (837249) 837249..838397 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
HZS99_RS04065 (838469) 838469..839452 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
HZS99_RS04070 (840263) 840263..840433 - 171 Protein_801 IS110 family transposase -
HZS99_RS04075 (840776) 840776..841345 - 570 WP_001290250.1 DUF4942 domain-containing protein -
HZS99_RS04080 (841442) 841442..841639 - 198 WP_000839276.1 DUF957 domain-containing protein -
HZS99_RS04085 (841651) 841651..842139 - 489 WP_000777545.1 DUF5983 family protein -
HZS99_RS04090 (842136) 842136..842510 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
HZS99_RS04095 (842600) 842600..842968 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZS99_RS04100 (843018) 843018..843661 - 644 Protein_807 antitoxin of toxin-antitoxin stability system -
HZS99_RS04105 (843680) 843680..843901 - 222 WP_000692300.1 DUF987 domain-containing protein -
HZS99_RS04110 (843964) 843964..844440 - 477 WP_001347688.1 RadC family protein -
HZS99_RS04115 (844456) 844456..844941 - 486 WP_029701480.1 antirestriction protein -
HZS99_RS04120 (844996) 844996..845814 - 819 WP_001234642.1 DUF932 domain-containing protein -
HZS99_RS04125 (845914) 845914..846147 - 234 WP_001119719.1 DUF905 family protein -
HZS99_RS04130 (846226) 846226..846681 - 456 WP_000581493.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T167337 WP_001094454.1 NZ_CP058748:c842510-842136 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T167337 NZ_CP075115:c3881838-3881530 [Salmonella enterica subsp. enterica serovar Eastbourne]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGATAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT167337 WP_001320394.1 NZ_CP058748:c842968-842600 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT167337 NZ_CP075115:c3882080-3881841 [Salmonella enterica subsp. enterica serovar Eastbourne]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References