Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4761164..4761680 Replicon chromosome
Accession NZ_CP058743
Organism Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag HZS96_RS23450 Protein ID WP_004192395.1
Coordinates 4761164..4761448 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag HZS96_RS23455 Protein ID WP_004192397.1
Coordinates 4761438..4761680 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS96_RS23425 (4756581) 4756581..4756844 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
HZS96_RS23430 (4756974) 4756974..4757147 + 174 WP_002886906.1 hypothetical protein -
HZS96_RS23435 (4757150) 4757150..4757893 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HZS96_RS23440 (4758250) 4758250..4760388 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HZS96_RS23445 (4760696) 4760696..4761160 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HZS96_RS23450 (4761164) 4761164..4761448 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS96_RS23455 (4761438) 4761438..4761680 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZS96_RS23460 (4761758) 4761758..4763668 - 1911 WP_004152270.1 PRD domain-containing protein -
HZS96_RS23465 (4763691) 4763691..4764845 - 1155 WP_004178372.1 lactonase family protein -
HZS96_RS23470 (4764912) 4764912..4765652 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T167327 WP_004192395.1 NZ_CP058743:c4761448-4761164 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T167327 NZ_CP075113:4654138-4654449 [Salmonella enterica subsp. enterica serovar Dublin]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGATCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT167327 WP_004192397.1 NZ_CP058743:c4761680-4761438 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT167327 NZ_CP075113:4654446-4654892 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References