Detailed information of TA system TA167326

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4681150..4681841
• Replicon: chromosome
• Accession: NZ_CP058743
• Organism: Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HZS96_RS23120
• Protein ID: WP_216422548.1
• Coordinates: 4681150..4681491 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A2A5MHA6
• Locus tag: HZS96_RS23125
• Protein ID: WP_019725272.1
• Coordinates: 4681515..4681841 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS96_RS23105 (4678130)	4678130..4679365	-	1236	WP_141400004.1	hypothetical protein	-
HZS96_RS23110 (4679804)	4679804..4680175	-	372	WP_240726111.1	hypothetical protein	-
HZS96_RS23115 (4680202)	4680202..4681035	-	834	WP_025987720.1	DUF4942 domain-containing protein	-
HZS96_RS23120 (4681150)	4681150..4681491	-	342	WP_216422548.1	TA system toxin CbtA family protein	Toxin
HZS96_RS23125 (4681515)	4681515..4681841	-	327	WP_019725272.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HZS96_RS23130 (4681855)	4681855..4682331	-	477	WP_019725273.1	DNA repair protein RadC	-
HZS96_RS23135 (4682341)	4682341..4682787	-	447	WP_025987722.1	antirestriction protein	-
HZS96_RS23140 (4682999)	4682999..4683688	-	690	WP_009309812.1	hypothetical protein	-
HZS96_RS23145 (4684253)	4684253..4685143	-	891	WP_019725276.1	YfjP family GTPase	-
HZS96_RS23150 (4685226)	4685226..4686314	-	1089	WP_216422887.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4664620..4704531	39911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (8-107)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12920.01 Da
• Isoelectric Point: 10.3418

>T167326 WP_216422548.1 NZ_CP058743:c4681491-4681150 [Klebsiella pneumoniae]
MKTLPATIQRAAKPRPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQKHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Nucleotide

• Length: 342 bp

>T167326 NZ_CP075113:c4652905-4652594 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12276.01 Da
• Isoelectric Point: 6.9560

>AT167326 WP_019725272.1 NZ_CP058743:c4681841-4681515 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Nucleotide

• Length: 327 bp

>AT167326 NZ_CP075113:c4652593-4652303 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MHA6