Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4034084..4034703 Replicon chromosome
Accession NZ_CP058743
Organism Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HZS96_RS19995 Protein ID WP_002892050.1
Coordinates 4034485..4034703 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HZS96_RS19990 Protein ID WP_002892066.1
Coordinates 4034084..4034458 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS96_RS19980 (4029236) 4029236..4030429 + 1194 WP_100908130.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZS96_RS19985 (4030452) 4030452..4033598 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HZS96_RS19990 (4034084) 4034084..4034458 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HZS96_RS19995 (4034485) 4034485..4034703 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HZS96_RS20000 (4034862) 4034862..4035428 + 567 WP_002892030.1 maltose O-acetyltransferase -
HZS96_RS20005 (4035400) 4035400..4035540 - 141 WP_004147370.1 hypothetical protein -
HZS96_RS20010 (4035561) 4035561..4036031 + 471 WP_002892026.1 YlaC family protein -
HZS96_RS20015 (4036006) 4036006..4037458 - 1453 Protein_3934 PLP-dependent aminotransferase family protein -
HZS96_RS20020 (4037559) 4037559..4038257 + 699 WP_002892021.1 GNAT family protein -
HZS96_RS20025 (4038254) 4038254..4038394 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HZS96_RS20030 (4038394) 4038394..4038657 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167325 WP_002892050.1 NZ_CP058743:4034485-4034703 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T167325 NZ_CP075113:c4343885-4343394 [Salmonella enterica subsp. enterica serovar Dublin]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT167325 WP_002892066.1 NZ_CP058743:4034084-4034458 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT167325 NZ_CP075113:c4344175-4343882 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCCGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References