Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2680883..2682471 | Replicon | chromosome |
| Accession | NZ_CP058743 | ||
| Organism | Klebsiella pneumoniae strain STLIN_10 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | HZS96_RS13335 | Protein ID | WP_004199851.1 |
| Coordinates | 2680883..2682205 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | HZS96_RS13340 | Protein ID | WP_002904790.1 |
| Coordinates | 2682205..2682471 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZS96_RS13320 (2675948) | 2675948..2678449 | + | 2502 | WP_023286424.1 | fimbria/pilus outer membrane usher protein | - |
| HZS96_RS13325 (2678437) | 2678437..2679441 | + | 1005 | WP_023286423.1 | fimbrial protein | - |
| HZS96_RS13330 (2679574) | 2679574..2680866 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| HZS96_RS13335 (2680883) | 2680883..2682205 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| HZS96_RS13340 (2682205) | 2682205..2682471 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| HZS96_RS13345 (2682736) | 2682736..2683062 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| HZS96_RS13350 (2683059) | 2683059..2683559 | - | 501 | WP_023286422.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| HZS96_RS13355 (2683537) | 2683537..2684916 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| HZS96_RS13360 (2685262) | 2685262..2686416 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| HZS96_RS13365 (2686397) | 2686397..2687320 | - | 924 | WP_008804925.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T167323 WP_004199851.1 NZ_CP058743:c2682205-2680883 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T167323 NZ_CP075113:c4195591-4195283 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT167323 WP_002904790.1 NZ_CP058743:c2682471-2682205 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT167323 NZ_CP075113:c4195833-4195594 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |