Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 863710..864367 Replicon chromosome
Accession NZ_CP058743
Organism Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HZS96_RS04325 Protein ID WP_002916310.1
Coordinates 863957..864367 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HZS96_RS04320 Protein ID WP_002916312.1
Coordinates 863710..863976 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS96_RS04295 (858866) 858866..860299 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HZS96_RS04300 (860418) 860418..861146 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HZS96_RS04305 (861196) 861196..861507 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HZS96_RS04310 (861671) 861671..862330 + 660 WP_002916317.1 hemolysin III family protein -
HZS96_RS04315 (862481) 862481..863464 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HZS96_RS04320 (863710) 863710..863976 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HZS96_RS04325 (863957) 863957..864367 + 411 WP_002916310.1 protein YgfX Toxin
HZS96_RS04330 (864374) 864374..864895 - 522 WP_002916308.1 flavodoxin FldB -
HZS96_RS04335 (864996) 864996..865892 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HZS96_RS04340 (865915) 865915..866628 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZS96_RS04345 (866634) 866634..868367 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T167314 WP_002916310.1 NZ_CP058743:863957-864367 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T167314 NZ_CP075113:309991-310359 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT167314 WP_002916312.1 NZ_CP058743:863710-863976 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167314 NZ_CP075113:309773-309994 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References