Detailed information of TA system TA167311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 325784..326370
• Replicon: chromosome
• Accession: NZ_CP058743
• Organism: Klebsiella pneumoniae strain STLIN_10

Toxin (Protein)

• Gene name: doc
• Uniprot ID: W8VD46
• Locus tag: HZS96_RS01510
• Protein ID: WP_002920800.1
• Coordinates: 326002..326370 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: W9B1V1
• Locus tag: HZS96_RS01505
• Protein ID: WP_004174006.1
• Coordinates: 325784..326005 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS96_RS01485 (321941)	321941..322867	+	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
HZS96_RS01490 (322864)	322864..324141	+	1278	WP_004188292.1	branched chain amino acid ABC transporter permease LivM	-
HZS96_RS01495 (324138)	324138..324905	+	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
HZS96_RS01500 (324907)	324907..325620	+	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
HZS96_RS01505 (325784)	325784..326005	+	222	WP_004174006.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HZS96_RS01510 (326002)	326002..326370	+	369	WP_002920800.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HZS96_RS01515 (326643)	326643..327959	+	1317	WP_004174008.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
HZS96_RS01520 (328066)	328066..328953	+	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
HZS96_RS01525 (328950)	328950..329795	+	846	WP_004145129.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
HZS96_RS01530 (329797)	329797..330867	+	1071	WP_004150074.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	286000..331604	45604

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13552.92 Da
• Isoelectric Point: 8.6410

>T167311 WP_002920800.1 NZ_CP058743:326002-326370 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T167311 NZ_CP075112:c4600641-4600267 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATCTTGGCCACTGCTCAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACACCGTATCACTTGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8151.15 Da
• Isoelectric Point: 4.7769

>AT167311 WP_004174006.1 NZ_CP058743:325784-326005 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT167311 NZ_CP075112:c4600883-4600641 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Structures

Toxin

• AlphaFold DB: A0A0H3GUD1

Antitoxin

• AlphaFold DB: A0A5E5YJY7