Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1607581..1608067 Replicon chromosome
Accession NZ_CP058741
Organism Streptococcus suis strain 13-00283-02

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag SSU1300283_RS07855 Protein ID WP_011922754.1
Coordinates 1607581..1607850 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag SSU1300283_RS07860 Protein ID WP_002938604.1
Coordinates 1607840..1608067 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU1300283_RS07830 1602836..1603810 - 975 WP_002937257.1 YvcK family protein -
SSU1300283_RS07835 1603807..1604694 - 888 WP_002937261.1 RNase adapter RapZ -
SSU1300283_RS07840 1604716..1605093 - 378 WP_002937263.1 RidA family protein -
SSU1300283_RS07845 1605425..1606714 - 1290 WP_014636745.1 IS4-like element ISSsu2 family transposase -
SSU1300283_RS07850 1606798..1607175 - 378 Protein_1529 MATE family efflux transporter -
SSU1300283_RS07855 1607581..1607850 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU1300283_RS07860 1607840..1608067 - 228 WP_002938604.1 hypothetical protein Antitoxin
SSU1300283_RS07865 1608339..1609685 - 1347 WP_014636890.1 asparagine--tRNA ligase -
SSU1300283_RS07870 1609700..1610881 - 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
SSU1300283_RS07875 1610878..1611375 - 498 WP_044667949.1 DUF5590 domain-containing protein -
SSU1300283_RS07880 1611678..1612127 + 450 WP_002938613.1 MarR family transcriptional regulator -
SSU1300283_RS07885 1612190..1612735 + 546 WP_002938614.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1605425..1606714 1289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T167305 WP_011922754.1 NZ_CP058741:c1607850-1607581 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T167305 NZ_CP075112:2390286-2390570 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT167305 WP_002938604.1 NZ_CP058741:c1608067-1607840 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT167305 NZ_CP075112:2390048-2390296 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGAGGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References