Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1055250..1055736 Replicon chromosome
Accession NZ_CP058741
Organism Streptococcus suis strain 13-00283-02

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag SSU1300283_RS05100 Protein ID WP_002935012.1
Coordinates 1055250..1055507 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag SSU1300283_RS05105 Protein ID WP_002935014.1
Coordinates 1055497..1055736 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU1300283_RS05080 1050882..1051952 + 1071 WP_014636926.1 tyrosine recombinase XerS -
SSU1300283_RS05085 1052022..1053532 - 1511 Protein_980 phosphomannomutase/phosphoglucomutase -
SSU1300283_RS05090 1053608..1054549 - 942 WP_002935009.1 sensor histidine kinase -
SSU1300283_RS05095 1054546..1055211 - 666 WP_009909826.1 response regulator transcription factor -
SSU1300283_RS05100 1055250..1055507 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU1300283_RS05105 1055497..1055736 - 240 WP_002935014.1 hypothetical protein Antitoxin
SSU1300283_RS05110 1055828..1057798 - 1971 WP_013730363.1 FtsX-like permease family protein -
SSU1300283_RS05115 1057799..1058551 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
SSU1300283_RS05120 1058568..1058951 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
SSU1300283_RS05125 1058964..1059104 - 141 WP_002935023.1 hypothetical protein -
SSU1300283_RS05130 1059203..1059937 - 735 WP_002935025.1 beta-carotene 15,15'-monooxygenase -
SSU1300283_RS05135 1059950..1060087 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T167304 WP_002935012.1 NZ_CP058741:c1055507-1055250 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T167304 NZ_CP075112:2014700-2014803 [Salmonella enterica subsp. enterica serovar Corvallis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT167304 WP_002935014.1 NZ_CP058741:c1055736-1055497 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT167304 NZ_CP075112:c2014805-2014660 [Salmonella enterica subsp. enterica serovar Corvallis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References