Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 801051..801534 Replicon chromosome
Accession NZ_CP058741
Organism Streptococcus suis strain 13-00283-02

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag SSU1300283_RS03925 Protein ID WP_009910443.1
Coordinates 801274..801534 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag SSU1300283_RS03920 Protein ID WP_012775256.1
Coordinates 801051..801272 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU1300283_RS03890 796053..796688 + 636 WP_002935723.1 phosphoserine phosphatase SerB -
SSU1300283_RS03895 796719..797369 - 651 WP_002935722.1 HAD family hydrolase -
SSU1300283_RS03900 797477..798604 + 1128 WP_002935718.1 glycerate kinase -
SSU1300283_RS03905 798595..798822 + 228 WP_002935708.1 hypothetical protein -
SSU1300283_RS03910 798832..799284 - 453 WP_013730449.1 DUF1694 domain-containing protein -
SSU1300283_RS03915 799434..800741 + 1308 WP_002935704.1 phosphopyruvate hydratase -
SSU1300283_RS03920 801051..801272 + 222 WP_012775256.1 hypothetical protein Antitoxin
SSU1300283_RS03925 801274..801534 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU1300283_RS03930 801701..802342 + 642 WP_002935700.1 HAD family hydrolase -
SSU1300283_RS03935 802375..802560 - 186 WP_002935693.1 hypothetical protein -
SSU1300283_RS03940 802624..803628 - 1005 WP_009910438.1 lactonase family protein -
SSU1300283_RS03945 803764..804930 + 1167 WP_002935690.1 AI-2E family transporter -
SSU1300283_RS03950 804920..806149 + 1230 WP_009910437.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T167303 WP_009910443.1 NZ_CP058741:801274-801534 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T167303 NZ_CP075112:c1021794-1021267 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGGGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCATAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT167303 WP_012775256.1 NZ_CP058741:801051-801272 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT167303 NZ_CP075112:c1022081-1021791 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References