Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1368765..1369251 Replicon chromosome
Accession NZ_CP058740
Organism Streptococcus suis strain 16085/3b

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag SSU16085_RS06565 Protein ID WP_002935012.1
Coordinates 1368994..1369251 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag SSU16085_RS06560 Protein ID WP_002935014.1
Coordinates 1368765..1369004 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU16085_RS06540 1364333..1365079 + 747 WP_011922411.1 ABC transporter permease -
SSU16085_RS06545 1365081..1365815 + 735 WP_011922410.1 ABC transporter permease -
SSU16085_RS06550 1365951..1366703 + 753 WP_011922409.1 ABC transporter ATP-binding protein -
SSU16085_RS06555 1366704..1368673 + 1970 Protein_1263 FtsX-like permease family protein -
SSU16085_RS06560 1368765..1369004 + 240 WP_002935014.1 hypothetical protein Antitoxin
SSU16085_RS06565 1368994..1369251 + 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSU16085_RS06570 1369281..1369826 + 546 Protein_1266 response regulator -
SSU16085_RS06575 1369950..1371206 + 1257 WP_002936698.1 ISL3 family transposase -
SSU16085_RS06580 1371241..1371378 + 138 Protein_1268 winged helix-turn-helix domain-containing protein -
SSU16085_RS06585 1371375..1372316 + 942 WP_002935009.1 sensor histidine kinase -
SSU16085_RS06590 1372392..1373900 + 1509 WP_013730362.1 phosphoglucomutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1369950..1371206 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T167300 WP_002935012.1 NZ_CP058740:1368994-1369251 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T167300 NZ_CP075112:215104-215589 [Salmonella enterica subsp. enterica serovar Corvallis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT167300 WP_002935014.1 NZ_CP058740:1368765-1369004 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT167300 NZ_CP075112:214829-215116 [Salmonella enterica subsp. enterica serovar Corvallis]
ATGCTATACAATGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References