Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1245299..1245842 Replicon chromosome
Accession NZ_CP058740
Organism Streptococcus suis strain 16085/3b

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag SSU16085_RS05955 Protein ID WP_002943355.1
Coordinates 1245573..1245842 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag SSU16085_RS05950 Protein ID WP_002326825.1
Coordinates 1245299..1245571 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSU16085_RS05905 1240553..1240783 + 231 WP_000659121.1 hypothetical protein -
SSU16085_RS05910 1240854..1241045 + 192 WP_000503424.1 hypothetical protein -
SSU16085_RS05915 1241099..1242202 + 1104 Protein_1135 recombinase family protein -
SSU16085_RS05920 1242291..1242530 + 240 WP_000635249.1 peptide-binding protein -
SSU16085_RS05925 1242579..1242662 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
SSU16085_RS05930 1242787..1243524 + 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
SSU16085_RS05935 1243694..1243954 + 261 Protein_1139 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
SSU16085_RS05940 1244057..1244953 + 897 WP_002326827.1 ParA family protein -
SSU16085_RS05945 1245072..1245281 + 210 WP_000527318.1 peptide-binding protein -
SSU16085_RS05950 1245299..1245571 + 273 WP_002326825.1 antitoxin Antitoxin
SSU16085_RS05955 1245573..1245842 + 270 WP_002943355.1 zeta toxin family protein Toxin
SSU16085_RS05960 1245940..1246287 + 348 Protein_1144 DUF4368 domain-containing protein -
SSU16085_RS05965 1246254..1247213 + 960 Protein_1145 hypothetical protein -
SSU16085_RS05970 1247284..1247583 + 300 WP_024408864.1 hypothetical protein -
SSU16085_RS05975 1247597..1247887 + 291 WP_024408865.1 membrane protein -
SSU16085_RS05980 1247983..1248621 + 639 WP_192062955.1 peptidylprolyl isomerase -
SSU16085_RS05985 1248660..1249736 + 1077 WP_044763948.1 toprim domain-containing protein -
SSU16085_RS05990 1249790..1250017 + 228 WP_000110922.1 hypothetical protein -
SSU16085_RS05995 1250014..1250403 + 390 WP_000048066.1 hypothetical protein -
SSU16085_RS06000 1250453..1250749 + 297 WP_002936411.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) - 1103839..1298421 194582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T167299 WP_002943355.1 NZ_CP058740:1245573-1245842 [Streptococcus suis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T167299 NZ_CP075111:76040-76615 [Salmonella enterica]
ATGAACCACACACCTTATCCCGTAGTTTTAGATGCTTGCGTACTGTATCCGTCATTTCTACGGGATTTACTGATTCGATT
GGGGCTGACCGGGTTGTACCAACCAAAATGGTCAGCCAGCATCGAAAATGAGTGGCAACGTAACCTGTTAGCAAACAGAA
CGGATCTAACTGAAGAGCAAATTAAACGCACTGCCACGCTAATGAATAAAGCCGTTCCTGATGCGTTGGTTACCGGCTTT
GAGCCTCTGATTGATAGCATTGATTTACCTGATGTAGATGATCGGCATGTTGCCGCAGCTGCTGTCCGTAGCAATGCTGA
AATCATTGTGACGTTGAATCTTAAAGATTTTCCGGCACCTGCTCTTGATGCCTTTGGTATCGAAGCGTTACATCCTGACG
ATTTTGTTATGGATTTATTCGATTTAAATAGAGCACTTGTGCTTTCGGCCGTAACTACGCAGCGCAGTAGTTTACGGAAA
CCGCCCGTGTCGGTTGATGAATATTTAGAAGCGCTGCTAAGGCAAGGTATGGCGCAAACCGTAAAAGAATTAAGCAAATA
CCGCATGCTGATTTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT167299 WP_002326825.1 NZ_CP058740:1245299-1245571 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT167299 NZ_CP075111:75579-76040 [Salmonella enterica]
ATGACAAACTCAATTCTTGATAGCCTTAGCCTTCCGGCTAAAGGGGAGATTGAGGCAGCTGTACGTGGACAAAGGGAGCT
TGCCGCCTACCTCTCCACAAAAATGGAAACACAGAAAATTTCGATTCAGGATGCAGATAACGTAACTCATCAAATCGAAC
TACCGACGTCTTCACTGACGTTGCTTATGTCGATTTTGGGTGAACTAGCACTTGGTAACGCGGTGCAAGTCGTTCCTGTG
CATGCTGAATTGACCACGCAGGAAGCCGCCAATATTCTTAATGTTTCACGCCCTCATATGGTGAAACTGCTGGAAGAGGG
GAAGCTGCCTTTTCATAAAACAGGTCGCCATCGCCGCGTGCTTTTCGCCGATTTGATGAAGTACAAGGATCAGCGAGATA
GCGATAGCAATATAGCTATGCAGGAGTTGGCAGATCTAAGCCAAGAGCTTGGACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References