Detailed information of TA system TA167298

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1216278..1217710
• Replicon: chromosome
• Accession: NZ_CP058740
• Organism: Streptococcus suis strain 16085/3b

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: SSU16085_RS05815
• Protein ID: WP_192062950.1
• Coordinates: 1216278..1217123 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: SSU16085_RS05820
• Protein ID: WP_192062951.1
• Coordinates: 1217120..1217710 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSU16085_RS05800	1211844..1214645	+	2802	WP_192062948.1	CHAP domain-containing protein	-
SSU16085_RS05805	1214783..1215793	+	1011	WP_192062949.1	Abi family protein	-
SSU16085_RS05810	1215908..1216192	+	285	Protein_1114	CHAP domain-containing protein	-
SSU16085_RS05815	1216278..1217123	-	846	WP_192062950.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
SSU16085_RS05820	1217120..1217710	-	591	WP_192062951.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / erm(B)	-	1103839..1298421	194582

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32365.01 Da
• Isoelectric Point: 5.2111

>T167298 WP_192062950.1 NZ_CP058740:c1217123-1216278 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQIEEVLADSEKGISFTIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTVYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFVKIIELLERFKSAP
IQNKQWQNYSKKYSYTKGISLADVLDEMINLITIIISTDSD

Nucleotide

• Length: 846 bp

>T167298 NZ_CP075111:c72618-72190 [Salmonella enterica]
ATGAAACAGCCGCGGACGAAGACGTATATGCTCGATACCAATATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAAAAGT
GCTGAAACGCCTCGAGCAGGCGGTGCTGCGCAATCACCGGATCGTAGTGTCGGCTATTACCTATGCGGAAATGCGCTTCG
GCGCGATCGGCAAAAAAGCCTCACCGCGCCACGCGCAGCTGGTAGACGCGTTCTGCGCGAGGCTCGATACCATTCTGCCG
TGGGATAAAGCCGCGGTGGATGCCACTACTGATATTAAAGCAGCACTGGCCGCCGCCGGCACGCCGATCGGCCCCAACGA
CACGGCGATTGCCGGACATGCCATTGCGGCCGGTGCCGTGCTGGTGACCAATAATACGCGGGAGTTTGAGCGGGTGCCGG
GTCTGAAGCTGGAAGACTGGGTCAAGTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23337.90 Da
• Isoelectric Point: 7.3110

>AT167298 WP_192062951.1 NZ_CP058740:c1217710-1217120 [Streptococcus suis]
MSKKEILLEFIENHNGIITYKDCKALKIPTIYLTRLEKEGIIYRVEKGIFLTQNGDYDEYYFFQYRYPKAIFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPENLNIHSVSKEYSELGITLVKTPMGNEVRVYDLERIICDFVIHREKIDTELFVKT
LQHYGNYSKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT167298 NZ_CP075111:c72845-72615 [Salmonella enterica]
ATGAGAACCGTATCGATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGATGGCGTCAG
CGAGCTCGAAATCGTGCGCGAGGGCGACAGCATCATCCTGCGCCCGGTCCGCCCGACCTGGGAGTCGTTCTTCCGGGAAG
AAAAGGCCGACGCGGACTTTATGGCCGAGCGCGAGGATGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA