Detailed information of TA system TA167296

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 537701..538354
• Replicon: chromosome
• Accession: NZ_CP058729
• Organism: Acinetobacter baumannii strain M164-3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HYO64_RS02640
• Protein ID: WP_000607072.1
• Coordinates: 537965..538354 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: HYO64_RS02635
• Protein ID: WP_001288210.1
• Coordinates: 537701..537958 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYO64_RS02615	533217..534224	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
HYO64_RS02620	534243..534620	+	378	WP_001216380.1	50S ribosomal protein L17	-
HYO64_RS02625	534802..536292	+	1491	WP_049081867.1	NAD(P)/FAD-dependent oxidoreductase	-
HYO64_RS02630	536341..537513	-	1173	WP_114155241.1	acyl-CoA dehydrogenase family protein	-
HYO64_RS02635	537701..537958	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
HYO64_RS02640	537965..538354	+	390	WP_000607072.1	membrane protein	Toxin
HYO64_RS02645	539124..540209	+	1086	WP_114155243.1	hypothetical protein	-
HYO64_RS02650	540287..540853	+	567	WP_000651536.1	rhombosortase	-
HYO64_RS02655	541041..543236	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15663.97 Da
• Isoelectric Point: 10.3890

>T167296 WP_000607072.1 NZ_CP058729:537965-538354 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVDWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T167296 NZ_CP075110:c4604840-4604529 [Salmonella enterica]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGCAGTGGCGTACGAATTATCTATTTTCATCGTAGTCAACGGTATGAGGTTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT167296 WP_001288210.1 NZ_CP058729:537701-537958 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT167296 NZ_CP075110:c4604528-4604238 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7