Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3928116..3928770 Replicon chromosome
Accession NZ_CP058725
Organism Escherichia coli strain S171-1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag HZS87_RS19185 Protein ID WP_000244777.1
Coordinates 3928363..3928770 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HZS87_RS19180 Protein ID WP_000354046.1
Coordinates 3928116..3928382 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS87_RS19155 (3923285) 3923285..3924028 + 744 WP_000951962.1 SDR family oxidoreductase -
HZS87_RS19160 (3924085) 3924085..3925518 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
HZS87_RS19165 (3925563) 3925563..3925874 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HZS87_RS19170 (3926038) 3926038..3926697 + 660 WP_000250274.1 hemolysin III family protein -
HZS87_RS19175 (3926893) 3926893..3927873 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
HZS87_RS19180 (3928116) 3928116..3928382 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HZS87_RS19185 (3928363) 3928363..3928770 + 408 WP_000244777.1 protein YgfX Toxin
HZS87_RS19190 (3928810) 3928810..3929331 - 522 WP_001055874.1 flavodoxin FldB -
HZS87_RS19195 (3929443) 3929443..3930339 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HZS87_RS19200 (3930364) 3930364..3931074 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZS87_RS19205 (3931080) 3931080..3932813 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T167288 WP_000244777.1 NZ_CP058725:3928363-3928770 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T167288 NZ_CP075110:816331-816744 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATGCTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGTTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT167288 WP_000354046.1 NZ_CP058725:3928116-3928382 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167288 NZ_CP075110:816084-816350 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References