Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1938540..1939158 Replicon chromosome
Accession NZ_CP058725
Organism Escherichia coli strain S171-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZS87_RS09595 Protein ID WP_001291435.1
Coordinates 1938940..1939158 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZS87_RS09590 Protein ID WP_000344800.1
Coordinates 1938540..1938914 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS87_RS09580 (1933629) 1933629..1934822 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZS87_RS09585 (1934845) 1934845..1937994 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZS87_RS09590 (1938540) 1938540..1938914 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZS87_RS09595 (1938940) 1938940..1939158 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZS87_RS09600 (1939330) 1939330..1939881 + 552 WP_000102564.1 maltose O-acetyltransferase -
HZS87_RS09605 (1939997) 1939997..1940467 + 471 WP_000136192.1 YlaC family protein -
HZS87_RS09610 (1940631) 1940631..1942181 + 1551 WP_063081929.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZS87_RS09615 (1942223) 1942223..1942576 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZS87_RS09625 (1942955) 1942955..1943266 + 312 WP_000409911.1 MGMT family protein -
HZS87_RS09630 (1943297) 1943297..1943869 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167281 WP_001291435.1 NZ_CP058725:1938940-1939158 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167281 NZ_CP075109:3636217-3636474 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGTCCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167281 WP_000344800.1 NZ_CP058725:1938540-1938914 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167281 NZ_CP075109:c3636392-3636060 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References