Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2271777..2272395 Replicon chromosome
Accession NZ_CP058719
Organism Escherichia coli strain M159-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZS86_RS11035 Protein ID WP_001291435.1
Coordinates 2271777..2271995 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZS86_RS11040 Protein ID WP_000344800.1
Coordinates 2272021..2272395 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS86_RS11000 (2267067) 2267067..2267639 + 573 WP_000779831.1 YbaY family lipoprotein -
HZS86_RS11005 (2267670) 2267670..2267981 - 312 WP_165369371.1 MGMT family protein -
HZS86_RS11015 (2268359) 2268359..2268712 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HZS86_RS11020 (2268754) 2268754..2270304 - 1551 WP_072643403.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZS86_RS11025 (2270468) 2270468..2270938 - 471 WP_000136192.1 YlaC family protein -
HZS86_RS11030 (2271054) 2271054..2271605 - 552 WP_000102564.1 maltose O-acetyltransferase -
HZS86_RS11035 (2271777) 2271777..2271995 - 219 WP_001291435.1 HHA domain-containing protein Toxin
HZS86_RS11040 (2272021) 2272021..2272395 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZS86_RS11045 (2272941) 2272941..2276090 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZS86_RS11050 (2276113) 2276113..2277306 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167253 WP_001291435.1 NZ_CP058719:c2271995-2271777 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167253 NZ_CP075107:299081-299449 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167253 WP_000344800.1 NZ_CP058719:c2272395-2272021 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167253 NZ_CP075107:298863-299084 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References