Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 76780..77302 Replicon plasmid pM172-1.3
Accession NZ_CP058717
Organism Escherichia coli strain M172-1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HYI45_RS26425 Protein ID WP_000220561.1
Coordinates 77021..77302 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HYI45_RS26420 Protein ID WP_000121743.1
Coordinates 76780..77031 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI45_RS26400 (72903) 72903..73256 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
HYI45_RS26405 (73393) 73393..73839 - 447 WP_001074384.1 hypothetical protein -
HYI45_RS26410 (73843) 73843..74685 - 843 WP_063116919.1 replication initiation protein -
HYI45_RS26415 (74706) 74706..75545 - 840 WP_024129959.1 replication initiation protein -
HYI45_RS26420 (76780) 76780..77031 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HYI45_RS26425 (77021) 77021..77302 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYI45_RS26430 (77541) 77541..77633 - 93 Protein_89 IS6 family transposase -
HYI45_RS26435 (77799) 77799..78998 - 1200 WP_000948429.1 IS91 family transposase -
HYI45_RS26440 (79008) 79008..79196 - 189 WP_000957857.1 hypothetical protein -
HYI45_RS26445 (79316) 79316..80746 + 1431 Protein_92 IS4-like element IS50R family transposase -
HYI45_RS26450 (80775) 80775..81569 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
HYI45_RS26455 (81590) 81590..81826 + 237 Protein_94 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-65 / qepA1 / blaTEM-1B / aph(3')-IIa / tet(A) / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / dfrA14 - 1..97389 97389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T167240 WP_000220561.1 NZ_CP058717:77021-77302 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T167240 NZ_CP075106:822851-823264 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167240 WP_000121743.1 NZ_CP058717:76780-77031 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167240 NZ_CP075106:822604-822870 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References