Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 28087..28609 Replicon plasmid pM172-1.3
Accession NZ_CP058717
Organism Escherichia coli strain M172-1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HYI45_RS26145 Protein ID WP_000220561.1
Coordinates 28328..28609 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HYI45_RS26140 Protein ID WP_000121743.1
Coordinates 28087..28338 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI45_RS26120 (24210) 24210..24563 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
HYI45_RS26125 (24700) 24700..25146 - 447 WP_001074384.1 hypothetical protein -
HYI45_RS26130 (25150) 25150..25992 - 843 WP_063116919.1 replication initiation protein -
HYI45_RS26135 (26013) 26013..26852 - 840 WP_024129959.1 replication initiation protein -
HYI45_RS26140 (28087) 28087..28338 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HYI45_RS26145 (28328) 28328..28609 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYI45_RS26150 (28848) 28848..28940 - 93 Protein_33 IS6 family transposase -
HYI45_RS26155 (29106) 29106..30305 - 1200 WP_000948429.1 IS91 family transposase -
HYI45_RS26160 (30315) 30315..30503 - 189 WP_000957857.1 hypothetical protein -
HYI45_RS26165 (30623) 30623..32053 + 1431 Protein_36 IS4-like element IS50R family transposase -
HYI45_RS26170 (32082) 32082..32876 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
HYI45_RS26175 (32897) 32897..33133 + 237 Protein_38 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-65 / qepA1 / blaTEM-1B / aph(3')-IIa / tet(A) / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / dfrA14 - 1..97389 97389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T167239 WP_000220561.1 NZ_CP058717:28328-28609 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T167239 NZ_CP075106:316026-316394 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167239 WP_000121743.1 NZ_CP058717:28087-28338 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167239 NZ_CP075106:315808-316029 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References