Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 4336961..4337599 Replicon chromosome
Accession NZ_CP058714
Organism Escherichia coli strain M172-1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HYI45_RS20755 Protein ID WP_000813794.1
Coordinates 4336961..4337137 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HYI45_RS20760 Protein ID WP_001270286.1
Coordinates 4337183..4337599 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI45_RS20735 (4332874) 4332874..4333755 - 882 Protein_4053 BenE family transporter YdcO -
HYI45_RS20740 (4333847) 4333847..4334383 + 537 WP_000429154.1 DNA-binding transcriptional regulator SutR -
HYI45_RS20745 (4334456) 4334456..4336417 + 1962 WP_012311648.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HYI45_RS20750 (4336509) 4336509..4336739 - 231 WP_000491567.1 DUF2554 family protein -
HYI45_RS20755 (4336961) 4336961..4337137 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HYI45_RS20760 (4337183) 4337183..4337599 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HYI45_RS20765 (4337678) 4337678..4339084 + 1407 WP_000760611.1 PLP-dependent aminotransferase family protein -
HYI45_RS20770 (4339329) 4339329..4340474 + 1146 WP_000034364.1 ABC transporter substrate-binding protein -
HYI45_RS20775 (4340492) 4340492..4341505 + 1014 WP_000220391.1 ABC transporter ATP-binding protein -
HYI45_RS20780 (4341506) 4341506..4342447 + 942 WP_001251303.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4331531..4332859 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T167223 WP_000813794.1 NZ_CP058714:4336961-4337137 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T167223 NZ_CP075062:2792051-2792158 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT167223 WP_001270286.1 NZ_CP058714:4337183-4337599 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT167223 NZ_CP075062:c2791998-2791937 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References