167210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 784011..784717 Replicon chromosome
Accession NZ_CP058714
Organism Escherichia coli strain M172-1

Toxin (Protein)


Gene name ypjF Uniprot ID V0SXW1
Locus tag HYI45_RS03910 Protein ID WP_000854677.1
Coordinates 784011..784379 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID V0SU84
Locus tag HYI45_RS03915 Protein ID WP_000065824.1
Coordinates 784400..784717 (-) Length 106 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYI45_RS03890 (779391) 779391..781034 + 1644 WP_001265639.1 fimbrial adhesin EcpD -
HYI45_RS03895 (781003) 781003..781713 + 711 WP_001361803.1 fimbrial chaperone EcpE -
HYI45_RS03900 (782026) 782026..782355 + 330 WP_001303809.1 YkgJ family cysteine cluster protein -
HYI45_RS03905 (782604) 782604..783218 - 615 WP_001019920.1 YagU family protein -
HYI45_RS03910 (784011) 784011..784379 - 369 WP_000854677.1 TA system toxin CbtA family protein Toxin
HYI45_RS03915 (784400) 784400..784717 - 318 WP_000065824.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HYI45_RS03920 (784737) 784737..784958 - 222 WP_001220307.1 DUF987 domain-containing protein -
HYI45_RS03925 (784967) 784967..785446 - 480 WP_000438147.1 RadC family protein -
HYI45_RS03930 (785458) 785458..785916 - 459 WP_000211834.1 antirestriction protein -
HYI45_RS03935 (786002) 786002..786238 - 237 Protein_772 DUF905 domain-containing protein -
HYI45_RS03945 (787722) 787722..787873 - 152 Protein_774 IS3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 756761..795703 38942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-111)

Antitoxin

(5-104)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13687.89 Da        Isoelectric Point: 8.2671

>T167210 WP_000854677.1 NZ_CP058714:c784379-784011 [Escherichia coli]
MKTLPATTPQAAKPCLSPVSVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTTTDILQARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

>T167210 NZ_CP075061:4689232-4689552 [Escherichia coli]
ATGAAAACTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGCAAATGTTACTGAC
AAGCCTGCTAGACCAGCACTATGGTCTCACGCTAAACGACACGCCGTTCAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCCGATGCCGTAAACTTTCTGGTTGAACGCTATGAACTAGTTCGTATTGACCAAAAAGGCTTC
TCTGTGCAAGATCAAGAACCTTGGTTAACCTCTATGGATGTTCACCGAGCACGATTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11964.46 Da        Isoelectric Point: 6.3163

>AT167210 WP_000065824.1 NZ_CP058714:c784717-784400 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAEYRKLDETFPHFISQMESMLTTGEMNPRHAHCVTLYH
DGFTCEADTLGSCGYVYIVVYSTQR

Download         Length: 318 bp

>AT167210 NZ_CP075061:4688885-4689211 [Escherichia coli]
ATGTCATTAATACCAGCCCATGAATGGGGACTACAAAGAGAAATTGTTCCACGGTTTGGAGCCAGATTAGTTCAGGAGGG
CAACCGGCTGCATTATCTGGCTGACAGGGCTAATTTGATGGGCAATTTCAGCGATACGGAATGCTTCAAATTGAATGACG
CATTTCCACACTTTATCAGTCAGATGGAATCGATGCTGACCACTGGTGAACTAATCCCCTGTCACCATCACTGTGTCACT
CTCTACCACAACGGTTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCGGTTTATCCCACTCA
ACGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SXW1


Antitoxin

Source ID Structure
AlphaFold DB V0SU84

References