Detailed information of TA system TA167207

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 235226..235931
• Replicon: chromosome
• Accession: NZ_CP058714
• Organism: Escherichia coli strain M172-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: HYI45_RS01260
• Protein ID: WP_000539521.1
• Coordinates: 235226..235612 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HYI45_RS01265
• Protein ID: WP_001280945.1
• Coordinates: 235602..235931 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYI45_RS01240 (231230)	231230..231856	+	627	WP_001295292.1	glutathione S-transferase GstB	-
HYI45_RS01245 (231853)	231853..232968	-	1116	WP_000555050.1	aldose sugar dehydrogenase YliI	-
HYI45_RS01250 (233079)	233079..233462	-	384	WP_000497137.1	biofilm formation regulator BssR	-
HYI45_RS01255 (233675)	233675..235000	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
HYI45_RS01260 (235226)	235226..235612	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HYI45_RS01265 (235602)	235602..235931	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
HYI45_RS01270 (236001)	236001..237329	-	1329	WP_000086869.1	GGDEF domain-containing protein	-
HYI45_RS01275 (237337)	237337..239685	-	2349	WP_000950337.1	EAL domain-containing protein	-
HYI45_RS01280 (239862)	239862..240773	-	912	WP_001236058.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T167207 WP_000539521.1 NZ_CP058714:235226-235612 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T167207 NZ_CP075061:c3683415-3683080 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT167207 WP_001280945.1 NZ_CP058714:235602-235931 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT167207 NZ_CP075061:c3683663-3683415 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6