Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 71868..72469 Replicon plasmid pS163-2.4
Accession NZ_CP058713
Organism Escherichia coli strain S163-2

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag HZS88_RS25095 Protein ID WP_001216034.1
Coordinates 72089..72469 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag HZS88_RS25090 Protein ID WP_001190712.1
Coordinates 71868..72089 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS88_RS25080 68867..70132 - 1266 WP_106693635.1 restriction endonuclease subunit S -
HZS88_RS25085 70129..71685 - 1557 WP_038997084.1 type I restriction-modification system subunit M -
HZS88_RS25090 71868..72089 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HZS88_RS25095 72089..72469 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HZS88_RS25100 72474..72653 + 180 WP_038997082.1 hypothetical protein -
HZS88_RS25105 72681..73598 + 918 Protein_66 hypothetical protein -
HZS88_RS25110 73655..74352 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
HZS88_RS25115 74377..74502 + 126 Protein_68 phage antirepressor Ant -
HZS88_RS25120 74623..74955 + 333 WP_224205061.1 phage antirepressor KilAC domain-containing protein -
HZS88_RS25125 74988..75839 - 852 WP_000611664.1 phage repressor protein C1 -
HZS88_RS25130 75950..76159 - 210 WP_072663797.1 c1 repressor inactivator -
HZS88_RS25135 76347..77327 + 981 WP_097410882.1 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS2 - 1..99340 99340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T167206 WP_001216034.1 NZ_CP058713:72089-72469 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T167206 NZ_CP075061:c3363307-3362909 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT167206 WP_001190712.1 NZ_CP058713:71868-72089 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT167206 NZ_CP075061:c3363534-3363307 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References