Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 96839..97361 Replicon plasmid pS163-2.2
Accession NZ_CP058711
Organism Escherichia coli strain S163-2

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag HZS88_RS24165 Protein ID WP_000220561.1
Coordinates 97080..97361 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag HZS88_RS24160 Protein ID WP_000121743.1
Coordinates 96839..97090 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS88_RS24135 (92078) 92078..92938 + 861 WP_063122221.1 hypothetical protein -
HZS88_RS24140 (92959) 92959..93315 - 357 WP_001714234.1 DNA distortion polypeptide 3 -
HZS88_RS24145 (93452) 93452..93898 - 447 WP_001074384.1 hypothetical protein -
HZS88_RS24150 (93902) 93902..94744 - 843 WP_000435064.1 replication initiation protein -
HZS88_RS24155 (94765) 94765..95604 - 840 WP_001352874.1 replication initiation protein -
HZS88_RS24160 (96839) 96839..97090 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
HZS88_RS24165 (97080) 97080..97361 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZS88_RS24170 (97711) 97711..98226 + 516 WP_001025387.1 J domain-containing protein -
HZS88_RS24175 (98300) 98300..98848 + 549 WP_001178641.1 hypothetical protein -
HZS88_RS24180 (98857) 98857..99126 + 270 WP_001006718.1 hypothetical protein -
HZS88_RS24185 (99116) 99116..99358 + 243 WP_000008708.1 hypothetical protein -
HZS88_RS24190 (99491) 99491..100195 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HZS88_RS24195 (100201) 100201..100341 + 141 WP_001044210.1 hypothetical protein -
HZS88_RS24200 (100827) 100827..101564 + 738 WP_001446887.1 recombinase family protein -
HZS88_RS24205 (101561) 101561..101785 + 225 WP_000743213.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / aac(3)-IId / floR / blaCTX-M-65 - 1..104573 104573
- flank IS/Tn floR - 99491..104407 4916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T167202 WP_000220561.1 NZ_CP058711:97080-97361 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T167202 NZ_CP075061:c2046481-2046374 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT167202 WP_000121743.1 NZ_CP058711:96839-97090 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT167202 NZ_CP075061:2046534-2046595 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References