Detailed information of TA system TA167192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 665520..666158
• Replicon: chromosome
• Accession: NZ_CP058709
• Organism: Escherichia coli strain S163-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: HZS88_RS03455
• Protein ID: WP_000813794.1
• Coordinates: 665982..666158 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HZS88_RS03450
• Protein ID: WP_001270286.1
• Coordinates: 665520..665936 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZS88_RS03430 (660672)	660672..661613	-	942	WP_001251313.1	ABC transporter permease	-
HZS88_RS03435 (661614)	661614..662627	-	1014	WP_000220399.1	ABC transporter ATP-binding protein	-
HZS88_RS03440 (662645)	662645..663790	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
HZS88_RS03445 (664035)	664035..665441	-	1407	WP_000760585.1	PLP-dependent aminotransferase family protein	-
HZS88_RS03450 (665520)	665520..665936	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
HZS88_RS03455 (665982)	665982..666158	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
HZS88_RS03460 (666380)	666380..666610	+	231	WP_000494244.1	YncJ family protein	-
HZS88_RS03465 (666702)	666702..668663	-	1962	WP_001301045.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
HZS88_RS03470 (668736)	668736..669272	-	537	WP_063120676.1	DNA-binding transcriptional regulator SutR	-
HZS88_RS03475 (669325)	669325..670539	+	1215	WP_071597387.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	670579..671844	1265

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T167192 WP_000813794.1 NZ_CP058709:c666158-665982 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T167192 NZ_CP075057:105948-106328 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT167192 WP_001270286.1 NZ_CP058709:c665936-665520 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT167192 NZ_CP075057:105727-105948 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• PDB: 6HPB