Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 4100431..4101002 Replicon chromosome
Accession NZ_CP058693
Organism Streptomyces sp. Rer75

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HYQ63_RS17080 Protein ID WP_179934730.1
Coordinates 4100431..4100805 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HYQ63_RS17085 Protein ID WP_179934731.1
Coordinates 4100805..4101002 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYQ63_RS17060 4096241..4096708 + 468 WP_039938834.1 Lrp/AsnC family transcriptional regulator -
HYQ63_RS17065 4096801..4097601 - 801 WP_179934729.1 hypothetical protein -
HYQ63_RS17070 4097682..4098323 - 642 WP_009717506.1 helix-turn-helix domain-containing protein -
HYQ63_RS17075 4098522..4100318 - 1797 WP_123107667.1 DEAD/DEAH box helicase -
HYQ63_RS17080 4100431..4100805 - 375 WP_179934730.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HYQ63_RS17085 4100805..4101002 - 198 WP_179934731.1 Arc family DNA-binding protein Antitoxin
HYQ63_RS17090 4101036..4102508 - 1473 WP_179934732.1 MFS transporter -
HYQ63_RS17095 4102606..4103670 - 1065 WP_179934733.1 putative sulfate exporter family transporter -
HYQ63_RS17100 4103708..4104268 - 561 WP_179934734.1 cysteine dioxygenase family protein -
HYQ63_RS17105 4104365..4105270 - 906 WP_179934735.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(12-80)

Antitoxin

Arc-like DNA binding domain

(4-30)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13706.53 Da        Isoelectric Point: 4.4315

>T167178 WP_179934730.1 NZ_CP058693:c4100805-4100431 [Streptomyces sp. Rer75]
MHYLTLPELLNLAERLGADEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESLARNHALVDGNKRLSWYATWVFL
HVNGHPLSADFDVDEAERFVLGVCQGELDVPKIAEGLPGFAVQV

Download         Length: 375 bp

>T167178 NZ_CP075037:c4132985-4132494 [Salmonella enterica subsp. enterica serovar Give]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7291.21 Da        Isoelectric Point: 6.2154

>AT167178 WP_179934731.1 NZ_CP058693:c4101002-4100805 [Streptomyces sp. Rer75]
MAALNLRFTDDELDALRKRAEAEGRSMQSFAHDAVIAAINEHSRLFNEAAAHVLKVSEELNRRLA

Download         Length: 198 bp

>AT167178 NZ_CP075037:c4133275-4132982 [Salmonella enterica subsp. enterica serovar Give]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References