Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 6008..6620 Replicon plasmid unnamed2
Accession NZ_CP058692
Organism Paracoccus pantotrophus strain ACCC10489

Toxin (Protein)


Gene name vapC Uniprot ID A0A7H9C207
Locus tag HYQ43_RS22640 Protein ID WP_024845492.1
Coordinates 6008..6403 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7H9C0X1
Locus tag HYQ43_RS22645 Protein ID WP_024845491.1
Coordinates 6393..6620 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYQ43_RS22620 2084..2995 - 912 WP_024846139.1 LysR family transcriptional regulator -
HYQ43_RS22625 3363..3659 + 297 Protein_4 type II toxin-antitoxin system VapC family toxin -
HYQ43_RS22630 3751..4818 - 1068 WP_024845494.1 hypothetical protein -
HYQ43_RS22635 5045..5929 + 885 WP_074991447.1 recombinase family protein -
HYQ43_RS22640 6008..6403 - 396 WP_024845492.1 PIN domain-containing protein Toxin
HYQ43_RS22645 6393..6620 - 228 WP_024845491.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HYQ43_RS22650 6830..8023 + 1194 WP_010400282.1 plasmid partitioning protein RepA -
HYQ43_RS22655 8007..8939 + 933 WP_024845490.1 plasmid partitioning protein RepB -
HYQ43_RS22660 9152..10363 + 1212 WP_024845489.1 replication initiation protein RepC -
HYQ43_RS22665 10563..11401 - 839 Protein_12 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73655 73655


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 4.1653

>T167177 WP_024845492.1 NZ_CP058692:c6403-6008 [Paracoccus pantotrophus]
MSAEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNETLVNCRRKAGLSWEEAGAFLEGVRALCPVEDLTLQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIINPFT

Download         Length: 396 bp

>T167177 NZ_CP075037:c3994998-3994714 [Salmonella enterica subsp. enterica serovar Give]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8487.83 Da        Isoelectric Point: 11.1585

>AT167177 WP_024845491.1 NZ_CP058692:c6620-6393 [Paracoccus pantotrophus]
MQVAKWGNSLAVRLPVELVRDLGLKEGDQIDLVKDDGKVRVRRLARADEVLTGLRRFRGKLPAAERLSRDAAHER

Download         Length: 228 bp

>AT167177 NZ_CP075037:c3995230-3994988 [Salmonella enterica subsp. enterica serovar Give]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAGGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAGGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H9C207

Antitoxin

Source ID Structure
AlphaFold DB A0A7H9C0X1

References