Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 101268..101803 Replicon plasmid unnamed1
Accession NZ_CP058691
Organism Paracoccus pantotrophus strain ACCC10489

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1I5P2D9
Locus tag HYQ43_RS20545 Protein ID WP_024846182.1
Coordinates 101268..101567 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1I5P292
Locus tag HYQ43_RS20550 Protein ID WP_028711008.1
Coordinates 101567..101803 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYQ43_RS20505 96491..97159 + 669 WP_024844137.1 ABC transporter ATP-binding protein -
HYQ43_RS20510 97355..97618 + 264 WP_179922266.1 hypothetical protein -
HYQ43_RS20515 97818..98171 + 354 WP_179922268.1 hypothetical protein -
HYQ43_RS20520 98278..99303 - 1026 WP_179922270.1 iron chelate uptake ABC transporter family permease subunit -
HYQ43_RS20525 99300..100107 - 808 Protein_111 ABC transporter substrate-binding protein -
HYQ43_RS20530 100171..100326 - 156 Protein_112 TonB-dependent receptor -
HYQ43_RS20535 100347..100568 - 222 Protein_113 transposase domain-containing protein -
HYQ43_RS20540 100569..100805 + 237 WP_024846181.1 hypothetical protein -
HYQ43_RS20545 101268..101567 - 300 WP_024846182.1 CcdB family protein Toxin
HYQ43_RS20550 101567..101803 - 237 WP_028711008.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HYQ43_RS20555 102084..102812 - 729 WP_024843951.1 IS21-like element ISPkr1 family helper ATPase IstB -
HYQ43_RS20560 102742..104310 - 1569 WP_028717560.1 IS21 family transposase -
HYQ43_RS20565 104505..104660 - 156 Protein_119 IS3 family transposase -
HYQ43_RS20570 104752..106026 - 1275 WP_179922272.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - glf 1..556977 556977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-98)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10669.40 Da        Isoelectric Point: 4.1564

>T167176 WP_024846182.1 NZ_CP058691:c101567-101268 [Paracoccus pantotrophus]
MARYDVYASPDGSGYLLDVQTDLLDNLSTRLVVPMMPVGASPPVLKQLNPIFDIQSERYVMVTQFMAAVPASILKTLAGS
LAQHDTEITGALDMLLTGV

Download         Length: 300 bp

>T167176 NZ_CP075037:c3952112-3951804 [Salmonella enterica subsp. enterica serovar Give]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCTCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8753.95 Da        Isoelectric Point: 10.2690

>AT167176 WP_028711008.1 NZ_CP058691:c101803-101567 [Paracoccus pantotrophus]
MQTQSVPKKPTNLSLDQGLLSEARSFGVNLSQAAEAGLRRAVREAKAEAWKRENAKAIEGVNRWVEENGLPLEKYRLF

Download         Length: 237 bp

>AT167176 NZ_CP075037:c3952354-3952115 [Salmonella enterica subsp. enterica serovar Give]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5P2D9

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5P292

References