Detailed information of TA system TA167175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1759373..1760034
• Replicon: chromosome
• Accession: NZ_CP058690
• Organism: Paracoccus pantotrophus strain ACCC10489

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HYQ43_RS16650
• Protein ID: WP_036747427.1
• Coordinates: 1759645..1760034 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7H9BYC9
• Locus tag: HYQ43_RS16645
• Protein ID: WP_024844293.1
• Coordinates: 1759373..1759636 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYQ43_RS16625	1754875..1755240	-	366	Protein_1705	hypothetical protein	-
HYQ43_RS16630	1755385..1756908	+	1524	WP_051481103.1	recombinase family protein	-
HYQ43_RS16635	1756908..1757816	+	909	WP_024844291.1	ParB/RepB/Spo0J family partition protein	-
HYQ43_RS16640	1757813..1758733	+	921	WP_024844292.1	ParB N-terminal domain-containing protein	-
HYQ43_RS16645	1759373..1759636	+	264	WP_024844293.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HYQ43_RS16650	1759645..1760034	+	390	WP_036747427.1	type II toxin-antitoxin system VapC family toxin	Toxin
HYQ43_RS16655	1760124..1761293	-	1170	Protein_1711	DEAD/DEAH box helicase	-
HYQ43_RS16660	1761312..1762811	-	1500	WP_179921699.1	IS66 family transposase	-
HYQ43_RS16665	1762871..1763218	-	348	WP_018000156.1	IS66 family insertion sequence element accessory protein TnpB	-
HYQ43_RS16670	1763428..1764578	+	1151	WP_155984417.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1753288..1770704	17416

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-120)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13599.59 Da
• Isoelectric Point: 5.1700

>T167175 WP_036747427.1 NZ_CP058690:1759645-1760034 [Paracoccus pantotrophus]
MLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILESVQVLALDVPADAEYGGIR
AELEAAGKPIGPNDLLIAAHAYAAGAILVTDNTGEFSRVRGLRVENWIR

Nucleotide

• Length: 390 bp

>T167175 NZ_CP075037:3314545-3314763 [Salmonella enterica subsp. enterica serovar Give]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9976.36 Da
• Isoelectric Point: 4.6558

>AT167175 WP_024844293.1 NZ_CP058690:1759373-1759636 [Paracoccus pantotrophus]
MPHPQPYSEPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPVRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAKEIDI

Nucleotide

• Length: 264 bp

>AT167175 NZ_CP075037:3314143-3314517 [Salmonella enterica subsp. enterica serovar Give]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7H9BYC9