Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1232342..1232871 Replicon chromosome
Accession NZ_CP058690
Organism Paracoccus pantotrophus strain ACCC10489

Toxin (Protein)


Gene name parE Uniprot ID A0A1I5JV80
Locus tag HYQ43_RS14100 Protein ID WP_024845134.1
Coordinates 1232342..1232629 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1I5JVF8
Locus tag HYQ43_RS14105 Protein ID WP_024845133.1
Coordinates 1232626..1232871 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYQ43_RS14070 1227678..1228451 + 774 Protein_1202 IS5-like element ISPpa8 family transposase -
HYQ43_RS14075 1228513..1228794 + 282 WP_085501511.1 transposase -
HYQ43_RS14080 1228903..1229178 - 276 Protein_1204 transposase -
HYQ43_RS14085 1229233..1230165 - 933 WP_028713484.1 IS5-like element ISPpa8 family transposase -
HYQ43_RS14090 1230355..1231527 + 1173 WP_036747930.1 ATP-binding protein -
HYQ43_RS14095 1231751..1232323 - 573 WP_143091279.1 hypothetical protein -
HYQ43_RS14100 1232342..1232629 - 288 WP_024845134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYQ43_RS14105 1232626..1232871 - 246 WP_024845133.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HYQ43_RS14110 1232976..1234337 - 1362 WP_024845132.1 plasmid recombination protein -
HYQ43_RS14115 1234330..1235187 - 858 WP_028710599.1 hypothetical protein -
HYQ43_RS14125 1235669..1236466 + 798 WP_024845130.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
HYQ43_RS14130 1236566..1236979 + 414 WP_024845129.1 YHS domain-containing protein -
HYQ43_RS14135 1237164..1237616 + 453 WP_024845128.1 CoA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10744.14 Da        Isoelectric Point: 6.0719

>T167174 WP_024845134.1 NZ_CP058690:c1232629-1232342 [Paracoccus pantotrophus]
MKALAFTVAATVDLEDIWDYTEGEWGLAQARRYVQELRDTCHALASGERRGRSVDVRPGYLKCLSGSHVIFFRDLGDTLE
IVRILHGAQDAERHL

Download         Length: 288 bp

>T167174 NZ_CP075037:1933289-1933444 [Salmonella enterica subsp. enterica serovar Give]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8709.78 Da        Isoelectric Point: 6.4652

>AT167174 WP_024845133.1 NZ_CP058690:c1232871-1232626 [Paracoccus pantotrophus]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHETKVKALEAALIAGEESGRAEGFDLDQFIARKMAGRN
A

Download         Length: 246 bp

>AT167174 NZ_CP075037:c1933277-1933219 [Salmonella enterica subsp. enterica serovar Give]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5JV80

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5JVF8

References