Detailed information of TA system TA167173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1196040..1196697
• Replicon: chromosome
• Accession: NZ_CP058690
• Organism: Paracoccus pantotrophus strain ACCC10489

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HYQ43_RS13900
• Protein ID: WP_179922156.1
• Coordinates: 1196040..1196366 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HYQ43_RS13905
• Protein ID: WP_179922158.1
• Coordinates: 1196479..1196697 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYQ43_RS13900	1196040..1196366	-	327	WP_179922156.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HYQ43_RS13905	1196479..1196697	-	219	WP_179922158.1	antitoxin MazE family protein	Antitoxin
HYQ43_RS13910	1196827..1196940	-	114	Protein_1170	IS110 family transposase	-
HYQ43_RS13915	1197150..1197932	-	783	Protein_1171	IS5 family transposase	-
HYQ43_RS13920	1198068..1199753	-	1686	WP_179921642.1	AIPR family protein	-
HYQ43_RS13925	1200111..1200356	-	246	WP_028711013.1	helix-turn-helix domain-containing protein	-
HYQ43_RS13930	1200466..1200789	+	324	WP_179922160.1	zinc ribbon domain-containing protein	-
HYQ43_RS13935	1200786..1200968	+	183	WP_028711011.1	hypothetical protein	-
HYQ43_RS13940	1200965..1201471	+	507	WP_179921644.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1188614..1209274	20660
	-	flank	IS/Tn	-	-	1197150..1197509	359

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (7-71)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11384.35 Da
• Isoelectric Point: 8.8566

>T167173 WP_179922156.1 NZ_CP058690:c1196366-1196040 [Paracoccus pantotrophus]
MTRGDLVAVALQGDHGKPRPALIIQADQFPGTATVTVLLVTSTLVDAPLLRLTVEPSPENGLRKPSQIMIDKPMTVRIDK
IGAAFGRLDDAALVSVNRSLALFLGLAG

Nucleotide

• Length: 327 bp

>T167173 NZ_CP075037:1918065-1918168 [Salmonella enterica subsp. enterica serovar Give]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8271.30 Da
• Isoelectric Point: 4.7434

>AT167173 WP_179922158.1 NZ_CP058690:c1196697-1196479 [Paracoccus pantotrophus]
MPTPVSERVQRRRDALRAAGLRPVQIWVPDTRRPGFADECRRQAALVAQADRRDAGLDDFMDAALFDMDDWE

Nucleotide

• Length: 219 bp

>AT167173 NZ_CP075037:c1918169-1918027 [Salmonella enterica subsp. enterica serovar Give]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG