Detailed information of TA system TA167172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1508146..1508744
• Replicon: chromosome
• Accession: NZ_CP058689
• Organism: Paracoccus pantotrophus strain ACCC10489

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A7H9BRU3
• Locus tag: HYQ43_RS07485
• Protein ID: WP_024846175.1
• Coordinates: 1508146..1508442 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: HYQ43_RS07490
• Protein ID: WP_024846176.1
• Coordinates: 1508445..1508744 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYQ43_RS07435	1503444..1503707	-	264	WP_024844956.1	hypothetical protein	-
HYQ43_RS07440	1503994..1504524	-	531	WP_024844957.1	hypothetical protein	-
HYQ43_RS07445	1504599..1504841	-	243	WP_028710477.1	hypothetical protein	-
HYQ43_RS07450	1504838..1505062	-	225	WP_024846170.1	hypothetical protein	-
HYQ43_RS07455	1505059..1505268	-	210	WP_024846171.1	hypothetical protein	-
HYQ43_RS07460	1505265..1505627	-	363	WP_024846172.1	hypothetical protein	-
HYQ43_RS07465	1505630..1505803	-	174	WP_155984408.1	hypothetical protein	-
HYQ43_RS07470	1505800..1506033	-	234	WP_024846173.1	hypothetical protein	-
HYQ43_RS07475	1506203..1506427	+	225	WP_074991154.1	XRE family transcriptional regulator	-
HYQ43_RS07480	1506566..1508068	+	1503	WP_179921216.1	serine protease	-
HYQ43_RS07485	1508146..1508442	+	297	WP_024846175.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HYQ43_RS07490	1508445..1508744	+	300	WP_024846176.1	putative addiction module antidote protein	Antitoxin
HYQ43_RS07495	1508758..1508931	+	174	WP_155984409.1	hypothetical protein	-
HYQ43_RS07500	1508971..1509903	+	933	WP_028713484.1	IS5-like element ISPpa8 family transposase	-
HYQ43_RS07505	1510274..1510414	-	141	WP_155984402.1	hypothetical protein	-
HYQ43_RS07510	1510615..1511298	+	684	WP_024846110.1	hypothetical protein	-
HYQ43_RS07515	1511392..1512666	-	1275	WP_177209352.1	outer membrane protein transport protein	-
HYQ43_RS07520	1512984..1513433	-	450	WP_024846108.1	DUF393 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1508971..1509903	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (4-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11088.84 Da
• Isoelectric Point: 10.9420

>T167172 WP_024846175.1 NZ_CP058689:1508146-1508442 [Paracoccus pantotrophus]
MIEIRQTDTFREWLLSLRDARAKQKIASRIQRLRFGNPGDVKPVGAGVSEMRINEGPGYRVYFVQRGSVLVVLLCGGTKR
RQQADIEQAKRLAAEMEG

Nucleotide

• Length: 297 bp

>T167172 NZ_CP075037:822599-823012 [Salmonella enterica subsp. enterica serovar Give]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CGCGCCAACACTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10363.61 Da
• Isoelectric Point: 4.2571

>AT167172 WP_024846176.1 NZ_CP058689:1508445-1508744 [Paracoccus pantotrophus]
MALETTAFDPAEYLDNDEAIAGYLSDALETGDGAFIADALGVVARAKGMKQIAEDAGLSRESLYRALSEKGNPEFSTVLK
VVAALGLRLSATPAHHPAE

Nucleotide

• Length: 300 bp

>AT167172 NZ_CP075037:822352-822618 [Salmonella enterica subsp. enterica serovar Give]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A7H9BRU3