Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 16663..17161 Replicon plasmid unnamed3
Accession NZ_CP058685
Organism Escherichia coli strain MBT-5

Toxin (Protein)


Gene name TsxA Uniprot ID A0A7L6LHZ8
Locus tag HZT35_RS30065 Protein ID WP_000868277.1
Coordinates 16663..16929 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID A0A3H7VMJ5
Locus tag HZT35_RS30070 Protein ID WP_001450803.1
Coordinates 16919..17161 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT35_RS30045 12812..13084 - 273 WP_074400780.1 hypothetical protein -
HZT35_RS30050 13346..13615 - 270 WP_000190069.1 hypothetical protein -
HZT35_RS30055 13738..14751 - 1014 WP_024176825.1 replication initiation protein -
HZT35_RS30060 16388..16612 + 225 WP_000749828.1 hypothetical protein -
HZT35_RS30065 16663..16929 + 267 WP_000868277.1 hypothetical protein Toxin
HZT35_RS30070 16919..17161 + 243 WP_001450803.1 hypothetical protein Antitoxin
HZT35_RS30075 17602..17931 + 330 WP_021558913.1 hypothetical protein -
HZT35_RS30080 17989..18267 + 279 WP_136748664.1 cobalamin biosynthesis protein CbiX -
HZT35_RS30085 18701..18883 + 183 WP_000833471.1 type II toxin-antitoxin system HicA family toxin -
HZT35_RS30090 18908..19345 + 438 WP_000466317.1 type II toxin-antitoxin system HicB family antitoxin -
HZT35_RS30095 19374..20078 - 705 WP_032274884.1 hypothetical protein -
HZT35_RS30100 20075..20836 - 762 WP_001097938.1 conjugal transfer protein TraL -
HZT35_RS30105 20846..21253 - 408 WP_001190621.1 hypothetical protein -
HZT35_RS30110 21599..21934 + 336 WP_000963832.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34196 34196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10205.74 Da        Isoelectric Point: 10.4299

>T167170 WP_000868277.1 NZ_CP058685:16663-16929 [Escherichia coli]
MKVRKGDRQYYLNKEGNMFHLVKRVKTFSKSATLGKTKATVKTVADLVFNEKAFDTIDFSRDGLRENDKEIVSMMIQEMN
NERGKNVN

Download         Length: 267 bp

>T167170 NZ_CP074714:2652556-2653293 [Bacillus thuringiensis]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCTGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGCTGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9288.69 Da        Isoelectric Point: 9.7120

>AT167170 WP_001450803.1 NZ_CP058685:16919-17161 [Escherichia coli]
MLTENTPENIKRLRQKIGLTQRECAEIFSMNPRTWRRKEEPAGTASGTALTPVEFKYLQLLAGEHPEYVLRKRDKPKCSE

Download         Length: 243 bp

>AT167170 NZ_CP074714:2653406-2653534 [Bacillus thuringiensis]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A3H7VMJ5

References