Detailed information of TA system TA167165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 5059500..5060093
• Replicon: chromosome
• Accession: NZ_CP058682
• Organism: Escherichia coli strain MBT-5

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: HZT35_RS25930
• Protein ID: WP_202892808.1
• Coordinates: 5059500..5059835 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: U9Y2K1
• Locus tag: HZT35_RS25935
• Protein ID: WP_001223208.1
• Coordinates: 5059842..5060093 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT35_RS25910	5054946..5055968	-	1023	WP_001296689.1	ABC transporter permease	-
HZT35_RS25915	5055982..5057484	-	1503	WP_000205813.1	sugar ABC transporter ATP-binding protein	-
HZT35_RS25920	5057624..5058580	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
HZT35_RS25925	5058890..5059420	+	531	WP_000055075.1	inorganic diphosphatase	-
HZT35_RS25930	5059500..5059835	-	336	WP_202892808.1	type II toxin-antitoxin system ChpB family toxin	Toxin
HZT35_RS25935	5059842..5060093	-	252	WP_001223208.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
HZT35_RS25940	5060305..5060646	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
HZT35_RS25945	5060649..5064427	-	3779	Protein_5080	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-109)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 11816.60 Da
• Isoelectric Point: 5.0357

>T167165 WP_202892808.1 NZ_CP058682:c5059835-5059500 [Escherichia coli]
VNLNGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLVNQVRM
MDLRARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 336 bp

>T167165 NZ_CP074711:26949-27236 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.58 Da
• Isoelectric Point: 4.4201

>AT167165 WP_001223208.1 NZ_CP058682:c5060093-5059842 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT167165 NZ_CP074711:27223-27537 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTAAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U9LQ26