Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2785614..2786140 | Replicon | chromosome |
| Accession | NZ_CP058682 | ||
| Organism | Escherichia coli strain MBT-5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HZT35_RS14115 | Protein ID | WP_000323025.1 |
| Coordinates | 2785614..2785901 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HZT35_RS14120 | Protein ID | WP_000534858.1 |
| Coordinates | 2785901..2786140 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT35_RS14070 | 2780637..2780852 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| HZT35_RS14075 | 2781606..2781821 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| HZT35_RS14080 | 2782122..2782334 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HZT35_RS14085 | 2782389..2782478 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| HZT35_RS14090 | 2782756..2783509 | - | 754 | Protein_2755 | antitermination protein | - |
| HZT35_RS14095 | 2783523..2784572 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| HZT35_RS14100 | 2784574..2784852 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| HZT35_RS14105 | 2784919..2785170 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| HZT35_RS14110 | 2785387..2785542 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HZT35_RS14115 | 2785614..2785901 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HZT35_RS14120 | 2785901..2786140 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HZT35_RS14125 | 2786165..2786470 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| HZT35_RS14130 | 2786673..2787005 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| HZT35_RS14135 | 2787442..2788782 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| HZT35_RS14140 | 2788816..2789235 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| HZT35_RS14145 | 2789276..2790241 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| HZT35_RS14150 | 2790222..2790743 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| HZT35_RS14155 | 2790727..2790954 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2750288..2800265 | 49977 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T167159 WP_000323025.1 NZ_CP058682:c2785901-2785614 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T167159 NZ_CP074707:9097-9390 [Acinetobacter baumannii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGGGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTGAGAGGCGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGGGATCAATTTAA
GAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTGAGAGGCGATCTTGCAGGTTGCTATAAAA
TTAAATTATTAAAAGCTGGTGTCAGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATCACAGTCGGG
AAACGAGCTGATAGCATAGTTTATGACGAAGCTAAAAAGCGCATTAAAGACTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT167159 WP_000534858.1 NZ_CP058682:c2786140-2785901 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT167159 NZ_CP074707:8862-9107 [Acinetobacter baumannii]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTGTTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCCTATTCCATCCTTAAAGAACAAGGTATTGCACC
TACAGATTTCTTTACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTACCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTGTTAGCTCTTGTCCGTAAGCGCATTAATGACCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|