Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2484074..2484545 | Replicon | chromosome |
| Accession | NZ_CP058682 | ||
| Organism | Escherichia coli strain MBT-5 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | HZT35_RS12545 | Protein ID | WP_001303511.1 |
| Coordinates | 2484074..2484352 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | HZT35_RS12550 | Protein ID | WP_001302048.1 |
| Coordinates | 2484354..2484545 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT35_RS12520 | 2479724..2482375 | - | 2652 | WP_000105101.1 | exodeoxyribonuclease VIII | - |
| HZT35_RS12525 | 2482474..2482749 | - | 276 | WP_001307773.1 | hypothetical protein | - |
| HZT35_RS12530 | 2482823..2482999 | - | 177 | WP_000245534.1 | hypothetical protein | - |
| HZT35_RS12535 | 2482993..2483214 | - | 222 | WP_000560218.1 | killing protein KilR | - |
| HZT35_RS12540 | 2483635..2483787 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
| HZT35_RS12545 | 2484074..2484352 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HZT35_RS12550 | 2484354..2484545 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| HZT35_RS12555 | 2484566..2484937 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| HZT35_RS12560 | 2485035..2485337 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| HZT35_RS12565 | 2485334..2485759 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| HZT35_RS12570 | 2485781..2486743 | + | 963 | WP_001444941.1 | helix-turn-helix domain-containing protein | - |
| HZT35_RS12575 | 2486750..2487491 | + | 742 | Protein_2455 | ATP-binding protein | - |
| HZT35_RS12580 | 2487517..2488278 | + | 762 | WP_000450872.1 | DUF1627 domain-containing protein | - |
| HZT35_RS12585 | 2488311..2488592 | + | 282 | WP_000603384.1 | DNA-binding protein | - |
| HZT35_RS12590 | 2488589..2488816 | + | 228 | WP_000699809.1 | hypothetical protein | - |
| HZT35_RS12595 | 2488809..2489120 | + | 312 | WP_001289673.1 | hypothetical protein | - |
| HZT35_RS12600 | 2489248..2489466 | + | 219 | WP_000683609.1 | DUF4014 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2476326..2544736 | 68410 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T167156 WP_001303511.1 NZ_CP058682:c2484352-2484074 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T167156 NZ_CP074704:37955-38257 [Escherichia coli]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT167156 WP_001302048.1 NZ_CP058682:c2484545-2484354 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT167156 NZ_CP074704:38328-38666 [Escherichia coli]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACAT
GAATAAAAAAGCAGCCTGA
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACAT
GAATAAAAAAGCAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|