167134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 35659..36184 Replicon plasmid pMS114_2
Accession NZ_CP058673
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name ccdB Uniprot ID F0JY91
Locus tag HWV51_RS24775 Protein ID WP_001159869.1
Coordinates 35879..36184 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag HWV51_RS24770 Protein ID WP_000813630.1
Coordinates 35659..35877 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS24925 31347..31497 - 151 Protein_31 hypothetical protein -
HWV51_RS24750 31450..31680 - 231 WP_252990174.1 IS66 family insertion sequence element accessory protein TnpB -
HWV51_RS24755 32558..33208 + 651 Protein_33 transposase -
HWV51_RS24760 33486..34082 - 597 Protein_34 IS66 family transposase -
HWV51_RS24765 34172..34600 - 429 Protein_35 hypothetical protein -
HWV51_RS24770 35659..35877 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HWV51_RS24775 35879..36184 + 306 WP_001159869.1 type II toxin-antitoxin system toxin CcdB Toxin
HWV51_RS24780 36185..36385 + 201 Protein_38 phage integrase family protein -
HWV51_RS24785 36370..37281 - 912 WP_000549737.1 DMT family transporter -
HWV51_RS24790 37398..37535 + 138 Protein_40 Lrp/AsnC family transcriptional regulator -
HWV51_RS24795 37535..38584 + 1050 Protein_41 IS4 family transposase -
HWV51_RS24800 38684..40057 - 1374 WP_000244368.1 IS4-like element ISEc13 family transposase -
HWV51_RS24805 40269..40592 - 324 Protein_43 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..51521 51521
- inside IScluster/Tn - - 30499..43208 12709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11678.46 Da        Isoelectric Point: 6.4674

>T167134 WP_001159869.1 NZ_CP058673:35879-36184 [Salmonella enterica]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTSDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T167134 NZ_CP074701:c781031-780855 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT167134 WP_000813630.1 NZ_CP058673:35659-35877 [Salmonella enterica]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT167134 NZ_CP074701:c780809-780393 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2SIB9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References