167133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 228526..230149 Replicon plasmid pMS114_1
Accession NZ_CP058672
Organism Salmonella enterica strain MS114

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HWV51_RS24510 Protein ID WP_000088046.1
Coordinates 228526..229851 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HWV51_RS24515 Protein ID WP_024136327.1
Coordinates 229856..230149 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV51_RS24470 223713..223910 + 198 WP_000710701.1 hypothetical protein -
HWV51_RS24475 224246..224734 + 489 WP_244780211.1 hypothetical protein -
HWV51_RS24480 225134..225937 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
HWV51_RS24485 225937..226773 + 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
HWV51_RS24490 226920..227279 - 360 WP_239698373.1 HNH endonuclease -
HWV51_RS24495 227279..227734 - 456 WP_223229031.1 hypothetical protein -
HWV51_RS24500 227747..228157 - 411 WP_000985911.1 hypothetical protein -
HWV51_RS24505 228259..228465 - 207 WP_000134171.1 hypothetical protein -
HWV51_RS24510 228526..229851 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
HWV51_RS24515 229856..230149 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
HWV51_RS24520 230753..231145 - 393 WP_000341066.1 hypothetical protein -
HWV51_RS24525 231518..231859 + 342 WP_001151575.1 hypothetical protein -
HWV51_RS24530 231951..232142 + 192 WP_000398480.1 hypothetical protein -
HWV51_RS24535 232192..232473 + 282 WP_000077926.1 hypothetical protein -
HWV51_RS24920 232814..232945 - 132 WP_000374059.1 hypothetical protein -
HWV51_RS24540 233036..234277 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3'')-Ib / aph(6)-Id iutA / iucD / iucC / iucB / iucA / fdeC 1..242694 242694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T167133 WP_000088046.1 NZ_CP058672:c229851-228526 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T167133 NZ_CP074701:376144-376246 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT167133 WP_024136327.1 NZ_CP058672:c230149-229856 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT167133 NZ_CP074701:c376284-376013 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGATTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References